2-Amino-N,N-dimethyl-3-phenylpropanamidehydrochloride

Base Information

• Chemical Name: 2-Amino-N,N-dimethyl-3-phenylpropanamidehydrochloride
• CAS No.: 1175090-79-5
• Molecular Formula: C₁₁H₁₆N₂O*ClH
• Molecular Weight: 228.722
• Mol file: 1175090-79-5.mol

Synonyms:

Chemical Property of 2-Amino-N,N-dimethyl-3-phenylpropanamidehydrochloride

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

2-Amino-N,N-dimethyl-3-phenylpropanamidehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Amino-N,N-dimethyl-3-phenylpropanamidehydrochloride

There total 9 articles about 2-Amino-N,N-dimethyl-3-phenylpropanamidehydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

(S)-tert-butyl 1-(dimethylamino)-1-oxo-3-phenylpropan-2-ylcarbamate (78800-68-7) → (S)-2-Amino-N,N-dimethyl-3-phenyl-propionamide hydrochloride (123665-42-9,1175090-79-5)

Guidance literature:

With hydrogenchloride; In methanol; water; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1021/acs.orglett.1c02830

Reference yield: 85.0%

Boc-D-Phe-OH (18942-49-9) + dimethyl amine (124-40-3) → (R)-2-amino-N,N-dimethyl-3-phenyl-propionamide hydrochloride (1175090-79-5)

Guidance literature:

Boc-D-Phe-OH; dimethyl amine; With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; at 20 ℃; for 3h; Inert atmosphere;

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 3h; Inert atmosphere;

DOI:10.1021/ja5117638

Reference yield:

→ N-t-butoxycarbonyl-L-phenylalanine 4-nitrophenyl ester (7535-56-0) + (S)-2-Amino-N,N-dimethyl-3-phenyl-propionamide hydrochloride (123665-42-9,1175090-79-5)

Guidance literature:

upstream raw materials:

(S)-tert-butyl 1-(dimethylamino)-1-oxo-3-phenylpropan-2-ylcarbamate

N-tert-butoxycarbonyl-L-phenylalanine

dimethyl amine

((R)-1-Dimethylcarbamoyl-2-phenyl-ethyl)-carbamic acid tert-butyl ester

Downstream raw materials:

N,N-dimethyl-N²-(2-oxo-2,5-dihydro-1,3-thiazol-4-yl)-L-phenylalaninamide

N-[(2S)-2-amino-3-phenylpropyl]-N,N-dimethylamine

tert-butyl (S)-(1-(dimethylamino)-3-phenylpropan-2-yl)carbamate

Refernces

• 1、 Gediya, Shweta K.,Vyas, Vijyesh K.,Clarkson, Guy J.,Wills, Martin. "Asymmetric Transfer Hydrogenation of α-Keto Amides; Highly Enantioselective Formation of Malic Acid Diamides and α-Hydroxyamides". supporting information. p. 7803 - 7807. Retrieved 2021/10/20.
• 2、 -. "PD(II)-CATALYZED ENANTIOSELECTIVE C-H ARYLATION OF FREE CARBOXYLIC ACIDS". Page/Page column 16-17. . Retrieved 2019/11/12.