3-(4-BroMophenylthio)propionic acid, 98%

Base Information

• Chemical Name: 3-(4-BroMophenylthio)propionic acid, 98%
• CAS No.: 13735-04-1
• Molecular Formula: C9H9BrO2S
• Molecular Weight: 261.139
• Hs Code.: 2930909090
• Mol file: 13735-04-1.mol

Synonyms:

Chemical Property of 3-(4-BroMophenylthio)propionic acid, 98%

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 109-112℃
• Boiling Point: 388.542oC at 760 mmHg
• PKA: 4.25±0.10(Predicted)
• Flash Point: 188.784oC
• PSA: 62.60000
• Density: 1.62g/cm3
• LogP: 3.01590

Purity/Quality:

99% ^*data from raw suppliers

3-[(4-Bromophenyl)sulfanyl]propanoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(4-BroMophenylthio)propionic acid, 98%

There total 14 articles about 3-(4-BroMophenylthio)propionic acid, 98% which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3-Bromopropionic acid (590-92-1) + para-bromobenzenethiol (106-53-6) → 3-(4-Bromophenylsulfanyl)propanoic Acid (13735-04-1)

Guidance literature:

With sodium hydroxide; sodium carbonate; In water;

Reference yield: 97.0%

chloropropionic acid (107-94-8) + para-bromobenzenethiol (106-53-6) → 3-(4-Bromophenylsulfanyl)propanoic Acid (13735-04-1)

Guidance literature:

With sodium hydroxide; In water; Reflux;

DOI:10.1016/j.ejmech.2021.113601

Reference yield: 86.0%

para-bromobenzenethiol (106-53-6) + acrylic acid (79-10-7) → 3-(4-Bromophenylsulfanyl)propanoic Acid (13735-04-1)

Guidance literature:

With pyridine; quinoline; nickel dichloride; for 1h; Heating;

upstream raw materials:

chloropropionic acid

para-bromobenzenethiol

3-iodopropanoic acid

3-mercaptopropionic acid

Downstream raw materials:

6-bromo-2,3-dihydro-4H-1-benzothiopyran4-one

ethyl 4-<(4-(4-(1,1-dimethylethyl)phenyl)-(2H)-thiochromen-6-yl)ethynyl>benzoate

ethyl 4-<(4-trifluorosulfonyloxy-(2H)-thiochromen-6-yl)ethynyl>benzoate

ethyl 4-<(4-(4-ethylphenyl)-(2H)-thiochromen-6-yl)ethynyl>benzoate

Refernces

• 1、 Barral, Karine,Benmansour, Fatiha,Derviaux, Carine,Egea-Jimenez, Antonio Luis,Feracci, Mikael,Garcia, Manon,Hoffer, Laurent,Morelli, Xavier,Roche, Philippe,Zimmermann, Pascale,Leblanc, Rapha?l. "Fragment-based drug design targeting syntenin PDZ2 domain involved in exosomal release and tumour spread". . . Retrieved 2021/07/09.
• 2、 Naliapara, Yogesh,Pandya, Dhananjay. "Synthesis and anti cervical cancer activity of novel 5H-thiochromeno [4,3-d]pyrimidines". . p. 294 - 302. Retrieved 2020/04/21.