1-Phenyl-2-(trimethylsilyl)ethan-1-one

Base Information

• Chemical Name: 1-Phenyl-2-(trimethylsilyl)ethan-1-one
• CAS No.: 13735-78-9
• Molecular Formula: C11H16OSi
• Molecular Weight: 192.333
• DSSTox Substance ID: DTXSID30505593
• Nikkaji Number: J859.417A
• Wikidata: Q82360820
• Mol file: 13735-78-9.mol

Synonyms:13735-78-9;1-phenyl-2-(trimethylsilyl)ethanone;trimethylsilylacetophenone;SCHEMBL3754834;DTXSID30505593;1-Phenyl-2-trimethylsilanyl-ethanone;1-Phenyl-2-(trimethylsilyl)ethan-1-one

Chemical Property of 1-Phenyl-2-(trimethylsilyl)ethan-1-one

Chemical Property:

• Melting Point: 40-41 °C
• Boiling Point: 115 °C(Press: 4 Torr)
• PSA: 17.07000
• Density: 0.955 g/cm3
• LogP: 3.20750
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 192.097041664
• Heavy Atom Count: 13
• Complexity: 175

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C[Si](C)(C)CC(=O)C1=CC=CC=C1

Technology Process of 1-Phenyl-2-(trimethylsilyl)ethan-1-one

There total 19 articles about 1-Phenyl-2-(trimethylsilyl)ethan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

benzoyl chloride (98-88-4) + Chloromethyltrimethylsilane (2344-80-1) → 1-phenyl-2-(trimethylsilyl)ethanone (13735-78-9)

Guidance literature:

Chloromethyltrimethylsilane; With magnesium; In diethyl ether; at 20 ℃; for 1h;

benzoyl chloride; With copper(l) iodide; In diethyl ether; at -78 - 20 ℃; for 1h;

DOI:10.1021/acs.orglett.5b01582

Reference yield: 71.0%

trimethylsilylmethyllithium (1822-00-0) + benzoic acid (65-85-0,8013-63-6) → 1-phenyl-2-(trimethylsilyl)ethanone (13735-78-9)

Guidance literature:

In tetrahydrofuran; at 0 - 25 ℃; for 1h;

DOI:10.1055/s-1981-29526

Reference yield: 70.0%

(trimethylsilyl)methylmagnesium chloride (13170-43-9) + benzoyl chloride (98-88-4) → 1-phenyl-2-(trimethylsilyl)ethanone (13735-78-9)

Guidance literature:

With copper(l) iodide; In tetrahydrofuran; at -40 ℃; for 1.5h;

DOI:10.1016/0022-328X(91)86327-M

upstream raw materials:

benzoic acid methyl ester

trimethylsilylmethyllithium

benzoyltrimethylsilane

(dimethylamino)-p-tolyloxosulfonium methylide

Downstream raw materials:

((Z)-2-Trimethylsilanyl-1-trimethylsilanyloxy-vinyl)-benzene

3-Hydroxy-3-phenyl-4-trimethylsilanyl-butyric acid tert-butyl ester

1-styrenyloxytrimethylsilane

1-phenyl-2-(trimethylsilyl)ethanol