N-(4-((3-((methoxymethoxy)methyl)piperidin-1-yl)sulfonyl)phenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

Base Information

• Chemical Name: N-(4-((3-((methoxymethoxy)methyl)piperidin-1-yl)sulfonyl)phenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide
• CAS No.: 1374006-81-1
• Molecular Formula: C₂₀H₂₅F₃N₄O₅S
• Molecular Weight: 490.504
• Mol file: 1374006-81-1.mol

Synonyms:

Chemical Property of N-(4-((3-((methoxymethoxy)methyl)piperidin-1-yl)sulfonyl)phenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4-((3-((methoxymethoxy)methyl)piperidin-1-yl)sulfonyl)phenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

There total 4 articles about N-(4-((3-((methoxymethoxy)methyl)piperidin-1-yl)sulfonyl)phenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carbonyl chloride (129768-24-7) + C12H16N2O5S (349098-92-6) + chloromethyl methyl ether (107-30-2) → N-(4-((3-((methoxymethoxy)methyl)piperidin-1-yl)sulfonyl)phenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (1374006-81-1)

Guidance literature:

C₁₂H₁₆N₂O₅S; chloromethyl methyl ether; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;

With tin(II) chloride dihdyrate; In dichloromethane; at 20 ℃; for 6h;

1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carbonyl chloride;

DOI:10.1021/jm201699w

Reference yield:

3-(hydroxymethy)piperidine (4606-65-9) → N-(4-((3-((methoxymethoxy)methyl)piperidin-1-yl)sulfonyl)phenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (1374006-81-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium carbonate / acetone / 10 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

2.2: 6 h / 20 °C

With sodium carbonate; N-ethyl-N,N-diisopropylamine; In dichloromethane; acetone;

DOI:10.1021/jm201699w

Reference yield:

4-Nitrobenzenesulfonyl chloride (98-74-8) → N-(4-((3-((methoxymethoxy)methyl)piperidin-1-yl)sulfonyl)phenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (1374006-81-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium carbonate / acetone / 10 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

2.2: 6 h / 20 °C

With sodium carbonate; N-ethyl-N,N-diisopropylamine; In dichloromethane; acetone;

DOI:10.1021/jm201699w

upstream raw materials:

1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carbonyl chloride

C₁₂H₁₆N₂O₅S

chloromethyl methyl ether

3-(hydroxymethy)piperidine