2-chloro-2-phenylpropanal

Base Information

• Chemical Name: 2-chloro-2-phenylpropanal
• CAS No.: 70729-31-6
• Molecular Formula: C₉H₉ClO
• Molecular Weight: 168.623
• Mol file: 70729-31-6.mol

Synonyms:

Chemical Property of 2-chloro-2-phenylpropanal

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-chloro-2-phenylpropanal

There total 18 articles about 2-chloro-2-phenylpropanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-Phenylpropanal (34713-70-7) → 2-chloro-2-phenylpropanal (70729-31-6,70774-55-9,121569-35-5,6124-66-9)

Guidance literature:

2-Phenylpropanal; With polystyrene-supported 4-(phenylseleno)morpholine; In dichloromethane; for 5h; Heating;

With sulfuryl dichloride; In dichloromethane; at 0 ℃; for 1h;

In dichloromethane; for 1h; Heating;

DOI:10.1080/00304940309355844

Reference yield: 87.0%

N-chloropyrrolidine (19733-68-7) + 2-Phenylpropanal (34713-70-7) → 2-chloro-2-phenylpropanal (70729-31-6,70774-55-9,121569-35-5,6124-66-9) + C13H17NO (1383542-61-7)

Guidance literature:

With L-proline; In dichloromethane; at 0 - 20 ℃; for 48h;

DOI:10.1039/c2ob25595b

Reference yield: 48.0%

4-(2-phenyl-propenyl)-morpholine (28478-27-5) + N-chloro-N'-tosylbenzamidine (51673-52-0) → morpholine (110-91-8,99108-56-2) + 2-chloro-2-phenylpropanal (70729-31-6,70774-55-9,121569-35-5,6124-66-9) + N-[(4-methylphenyl)sulfonyl]benzenecarboximidamide (4115-16-6) + 4-[5-Methyl-2,5-diphenyl-1-(toluene-4-sulfonyl)-4,5-dihydro-1H-imidazol-4-yl]-morpholine (113676-41-8)

Guidance literature:

In dichloromethane; 1) -30 deg C, 30 min, 2) RT, 48 h;

DOI:10.1016/S0040-4020(01)86920-9

upstream raw materials:

dichloromethane

acetophenone

4-(2-phenyl-propenyl)-morpholine

N-chloro-N'-tosylbenzamidine

Downstream raw materials:

(+/-)-2-chloro-2-phenyl-propionic acid

rac-2-tert-Butyl-2,5-dihydro-5-methyl-5-phenyloxazol

2-Chloro-2-phenyl-propionaldehyde O-methyl-oxime

2-phenyl-2-piperidin-1-yl-propionaldehyde

Refernces

• 1、 Jimeno, Ciril,Cao, Lidong,Renaud, Philippe. "Trichloromethanesulfonyl chloride: A chlorinating reagent for aldehydes". . p. 1251 - 1255. Retrieved 2016/02/19.
• 2、 Masschelein, Kurt G.R.,Stevens, Christian V.. "Synthesis of 1,1-bisphosphono-2-aza-1,3-dienes, a new class of electron-deficient azadienes". . p. 4336 - 4338. Retrieved 2008/09/21.