Z-cyclohexyl-2 dimethyltertiobutylsilyloxy-1 methoxy-1 ethylene

Base Information

• Chemical Name: Z-cyclohexyl-2 dimethyltertiobutylsilyloxy-1 methoxy-1 ethylene
• CAS No.: 100340-52-1
• Molecular Formula: C₁₅H₃₀O₂Si
• Molecular Weight: 270.488
• Mol file: 100340-52-1.mol

Synonyms:

Chemical Property of Z-cyclohexyl-2 dimethyltertiobutylsilyloxy-1 methoxy-1 ethylene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Z-cyclohexyl-2 dimethyltertiobutylsilyloxy-1 methoxy-1 ethylene

There total 1 articles about Z-cyclohexyl-2 dimethyltertiobutylsilyloxy-1 methoxy-1 ethylene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl cyclohexylacetate (14352-61-5) + tert-butyldimethylsilyl chloride (18162-48-6) → Z-cyclohexyl-2 dimethyltertiobutylsilyloxy-1 methoxy-1 ethylene (100340-52-1) + E-cyclohexyl-2 dimethyltertiobutylsilyloxy-1 methoxy-1 ethylene (100340-51-0)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; Yield given. Yields of byproduct given. Title compound not separated from byproducts; 1.) -78 deg C;

DOI:10.1016/S0040-4020(01)96367-7

Reference yield:

cyclohexyl-2 dimethyltertiobutylsilyloxy-1 methoxy-1 ethylene (100340-51-0,100340-52-1) → 3-cyclohexylacrylic acid methyl ester (705-95-3)

Guidance literature:

Multi-step reaction with 2 steps

1: NaN(SiMe₃)2 / pentane / -15 deg C, 1.5 h; rt., 1 h

2: triethylamine / methanol / 12 h / Heating

With sodium hexamethyldisilazane; triethylamine; In methanol; pentane;

DOI:10.1016/S0040-4020(01)96367-7

Reference yield:

dichloromethane (75-09-2) + cyclohexyl-2 dimethyltertiobutylsilyloxy-1 methoxy-1 ethylene (100340-51-0,100340-52-1) → tert-Butyl-(2-chloro-3-cyclohexyl-1-methoxy-cyclopropoxy)-dimethyl-silane

Guidance literature:

With sodium hexamethyldisilazane; In pentane; -15 deg C, 1.5 h; rt., 1 h;

DOI:10.1016/S0040-4020(01)96367-7

upstream raw materials:

methyl cyclohexylacetate

tert-butyldimethylsilyl chloride

Downstream raw materials:

3-cyclohexylacrylic acid methyl ester

Refernces