Methyl 3-bromo-4-fluoro-6-methylbenzoate

Base Information

• Chemical Name: Methyl 3-bromo-4-fluoro-6-methylbenzoate
• CAS No.: 1564624-36-7
• Molecular Formula: C₉H₈BrFO₂
• Molecular Weight: 247.064
• Mol file: 1564624-36-7.mol

Synonyms:

Chemical Property of Methyl 3-bromo-4-fluoro-6-methylbenzoate

Chemical Property:

• Boiling Point: 260.7±35.0 °C(Predicted)
• Density: 1.506±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98% ^*data from raw suppliers

Methyl5-bromo-4-fluoro-2-methylbenzoate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methyl 3-bromo-4-fluoro-6-methylbenzoate

There total 3 articles about Methyl 3-bromo-4-fluoro-6-methylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methanol (67-56-1) + 5-bromo-4-fluoro-2-methylbenzoic acid (1427416-33-8) → methyl 5-bromo-4-fluoro-2-methylbenzoate (1564624-36-7)

Guidance literature:

With thionyl chloride; for 3h; Reflux;

Reference yield:

5-bromo-4-fluoro-2-methylbenzoic acid (1427416-33-8) + methyl iodide (74-88-4) → methyl 5-bromo-4-fluoro-2-methylbenzoate (1564624-36-7)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 40 ℃; for 15h; Inert atmosphere;

Reference yield:

4-fluoro-2-methylbenzoic acid (321-21-1) → methyl 5-bromo-4-fluoro-2-methylbenzoate (1564624-36-7)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid; N-Bromosuccinimide / 0 - 5 °C / Inert atmosphere

2: caesium carbonate / N,N-dimethyl-formamide / 15 h / 40 °C / Inert atmosphere

With N-Bromosuccinimide; sulfuric acid; caesium carbonate; In N,N-dimethyl-formamide;

upstream raw materials:

methanol

5-bromo-4-fluoro-2-methylbenzoic acid

methyl iodide

4-fluoro-2-methylbenzoic acid

Refernces

• 1、 -. "TETRAHYDRO-1 H-PYRAZINO[2,1 -AJISOINDOLYLQUINOLINE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE". Page/Page column 121; 122. . Retrieved 2019/12/28.