Piperidin-1-ium-4-ol;chloride

Base Information

• Chemical Name: Piperidin-1-ium-4-ol;chloride
• CAS No.: 5382-17-2
• Molecular Formula: C5H11NO^.HCl
• Molecular Weight: 137.609
• Hs Code.: 29333990
• Mol file: 5382-17-2.mol

Synonyms:AKOS015897745

Chemical Property of Piperidin-1-ium-4-ol;chloride

Chemical Property:

• Appearance/Colour: Off-white solid
• Vapor Pressure: 0.0214mmHg at 25°C
• Melting Point: 155-157 °C(lit.)
• Boiling Point: 222 °C at 760 mmHg
• Flash Point: 107.8 °C
• PSA: 32.26000
• LogP: 0.86150
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: methanol: soluble25mg/mL, clear, colorless
• Water Solubility.: very faint turbidity
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 137.0607417
• Heavy Atom Count: 8
• Complexity: 50

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Hydroxypiperidine hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1C[NH2+]CCC1O.[Cl-]
• Uses: 4-Hydroxypiperidine, HCl 4-Hydroxypiperidine hydrochloride is suitable for use in the Ugi-multi component reaction (MCR) to study the use of miniaturised-synthesis and Total Analysis System (mSYNTAS) in solution phase synthesis and on-line analysis of Ugi-MCRs. It may be used in the synthesis of acetic acid-piperidine-4-yl ester.

Technology Process of Piperidin-1-ium-4-ol;chloride

There total 4 articles about Piperidin-1-ium-4-ol;chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

t-butyl 4-hydroxy piperidine-1-carboxylate (109384-19-2) → piperidin-4-ol hydrochloride (5382-17-2)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 2h;

Reference yield:

4-HYDROXYPIPERIDINE (5382-16-1) → piperidin-4-ol hydrochloride (5382-17-2)

Guidance literature:

With hydrogenchloride; In water;

DOI:10.1039/c4ce02477j

Reference yield:

pyridin-4-ol (626-64-2,157061-69-3) → piperidin-4-ol hydrochloride (5382-17-2)

Guidance literature:

pyridin-4-ol; With palladium 10% on activated carbon; hydrogen; acetic acid; at 24 - 28 ℃; for 21h;

With hydrogenchloride; In methanol; water; Catalytic behavior;

DOI:10.1002/ejoc.202000695

upstream raw materials:

t-butyl 4-hydroxy piperidine-1-carboxylate

4-HYDROXYPIPERIDINE

pyridin-4-ol

Downstream raw materials:

4-hydroxypiperidinocyclohexyl carbonitrile

1-[3-(4-hydroxy-phenyl)-propyl]-piperidin-4-ol

t-butyl 4-hydroxy piperidine-1-carboxylate

4-benzyl-5-bromo-2-(4-hydroxypiperidino)pyridine

Refernces

• 1、 Tanaka, Nao,Usuki, Toyonobu. "Can Heteroarenes/Arenes Be Hydrogenated Over Catalytic Pd/C Under Ambient Conditions?". . p. 5514 - 5522. Retrieved 2020/07/24.
• 2、 -. "TETRAHYDROISOQUINOLINE DERIVED PRMT5-INHIBITORS". Page/Page column 120. . Retrieved 2016/03/19.