1H-Pyrrole, 1-methyl-2,3,5-triphenyl-

Base Information

• Chemical Name: 1H-Pyrrole, 1-methyl-2,3,5-triphenyl-
• CAS No.: 13901-77-4
• Molecular Formula: C23H19N
• Molecular Weight: 309.411
• Mol file: 13901-77-4.mol

Synonyms:

Chemical Property of 1H-Pyrrole, 1-methyl-2,3,5-triphenyl-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1H-Pyrrole, 1-methyl-2,3,5-triphenyl-

There total 20 articles about 1H-Pyrrole, 1-methyl-2,3,5-triphenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

benzyl-methyl-amine (103-67-3) + 1,3-diphenyl-2-propynone (7338-94-5) → 1-methyl-2,3,5-triphenyl-1H-pyrrole (13901-77-4)

Guidance literature:

benzyl-methyl-amine; 1,3-diphenyl-2-propynone; With potassium phosphate; In dimethyl sulfoxide; at 20 ℃; for 2h; Schlenk technique;

In dimethylsulfoxide-d6; at 140 ℃; for 12h; Schlenk technique; Inert atmosphere;

DOI:10.1039/c3cc43844a

Reference yield: 70.0%

benzoyltrimethylsilane (5908-41-8) + methylamine (74-89-5) + 1,3-diphenyl-propen-3-one (614-47-1) → 1-methyl-2,3,5-triphenyl-1H-pyrrole (13901-77-4)

Guidance literature:

benzoyltrimethylsilane; 1,3-diphenyl-propen-3-one; With 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; 1,8-diazabicyclo[5.4.0]undec-7-ene; isopropyl alcohol; In tetrahydrofuran; at 70 ℃; for 8h;

methylamine; With toluene-4-sulfonic acid; In tetrahydrofuran; ethanol; at 70 ℃; for 8h;

DOI:10.1021/ol049044t

Reference yield: 64.0%

N-Benzylidenemethylamine (622-29-7) + 2-phenyl-2-(2-pehnylethynyl)-1,3-dithiolane (183270-58-8) → 1-methyl-2,3,5-triphenyl-1H-pyrrole (13901-77-4)

Guidance literature:

2-phenyl-2-(2-pehnylethynyl)-1,3-dithiolane; With lithium di-n-butylcuprate; In tetrahydrofuran; at -78 ℃;

N-Benzylidenemethylamine; In tetrahydrofuran; at -78 ℃;

With trifluoroacetic acid; In tetrahydrofuran;

DOI:10.1021/ja0004736

upstream raw materials:

1,2,4-triphenylbutane-1,4-dione

methylamine hydrochloride

2,4,5-triphenylpyrrole

sodium t-butanolate

Downstream raw materials:

(Z)-1,2,4-triphenyl-2-butene-1,4-dione

3-(benzoyl-methyl-amino)-2,3-diphenyl-acrylic acid

2,4,6-triphenylpyrimidine