N-[(diethylamino)carbonothioyl]-4-fluorobenzamide

Base Information

• Chemical Name: N-[(diethylamino)carbonothioyl]-4-fluorobenzamide
• CAS No.: 203193-66-2
• Molecular Formula: C₁₂H₁₅FN₂OS
• Molecular Weight: 254.328
• Mol file: 203193-66-2.mol

Synonyms:

Chemical Property of N-[(diethylamino)carbonothioyl]-4-fluorobenzamide

Chemical Property:

Purity/Quality:

N-[(diethylamino)carbonothioyl]-4-fluorobenzamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[(diethylamino)carbonothioyl]-4-fluorobenzamide

There total 3 articles about N-[(diethylamino)carbonothioyl]-4-fluorobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

potassium thioacyanate (333-20-0) + 4-fluorobenzoyl chloride (403-43-0) + diethylamine (109-89-7) → N-(diethylcarbamothioyl)-4-fluorobenzamide (203193-66-2)

Guidance literature:

potassium thioacyanate; 4-fluorobenzoyl chloride; In acetone; at 50 ℃; for 1h;

diethylamine; In acetone; at 20 ℃; for 4h;

DOI:10.1016/j.poly.2021.115496

Reference yield:

4-fluorobenzoyl isothiocyanate (78225-74-8) + diethylamine (109-89-7) → N-(diethylcarbamothioyl)-4-fluorobenzamide (203193-66-2)

Guidance literature:

In acetone; Heating;

DOI:10.1016/j.jfluchem.2009.02.009

Reference yield:

4-fluorobenzoyl chloride (403-43-0) → N-(diethylcarbamothioyl)-4-fluorobenzamide (203193-66-2)

Guidance literature:

Multi-step reaction with 2 steps

1: acetone / 1 h / 20 °C / Inert atmosphere

2: acetone / 2 h / Inert atmosphere

In acetone;

DOI:10.1016/j.jfluchem.2018.08.004

upstream raw materials:

4-fluorobenzoyl isothiocyanate

diethylamine

4-fluorobenzoyl chloride

potassium thioacyanate

Refernces

• 1、 Salsi, Federico,Bulh?es Portapilla, Gisele,Schutjajew, Konstantin,Carneiro, Zumira Aparecida,Hagenbach, Adelheid,de Albuquerque, Sérgio,da Silva Maia, Pedro Ivo,Abram, Ulrich. "Thiosemicarbazones and thiadiazines derived from fluorinated benzoylthioureas: Synthesis, crystal structure and anti-Trypanosoma cruzi activity". . p. 52 - 61. Retrieved 2018/10/15.