6-Bromogramine

Base Information

• Chemical Name: 6-Bromogramine
• CAS No.: 59609-63-1
• Molecular Formula: C₁₁H₁₃BrN₂
• Molecular Weight: 253.142
• Mol file: 59609-63-1.mol

Synonyms:

Chemical Property of 6-Bromogramine

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

1-(6-Bromo-1H-indol-3-yl)-N,N-dimethylmethanamine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Bromogramine

There total 4 articles about 6-Bromogramine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.2%

6-bromo-1H-indole (52415-29-9) + formaldehyd (50-00-0,30525-89-4,61233-19-0) + dimethyl amine (124-40-3) → 6-Bromogramine (59609-63-1)

Guidance literature:

In water; acetic acid; Ambient temperature;

Reference yield:

6-bromo-1H-indole (52415-29-9) + eschenmoser's salt (33797-51-2) → 6-Bromogramine (59609-63-1)

Guidance literature:

In acetic acid; acetonitrile; at 20 ℃; for 3h;

DOI:10.1021/ja0659673

Reference yield:

3-(Dimethylaminomethyl)indole (87-52-5) → N-[(5-bromo-1H-indol-3-yl)methyl]-N,N-dimethylamine (830-93-3) + 6-Bromogramine (59609-63-1)

Guidance literature:

With bromine; In acetic acid; for 20h; Yield given. Yields of byproduct given. Title compound not separated from byproducts; Ambient temperature;

upstream raw materials:

6-bromo-1H-indole

formaldehyd

dimethyl amine

3-(Dimethylaminomethyl)indole

Downstream raw materials:

2-(6-bromo-1H-indol-3-yl)acetic acid

(6-bromo-1H-indol-3-yl)acetic acid methyl ester

2-(6-bromo-1H-indol-3-yl)acetonitrile