(6-Amino-2-methylthiopyrimidin-4-yl)dimethylamine

Base Information

• Chemical Name: (6-Amino-2-methylthiopyrimidin-4-yl)dimethylamine
• CAS No.: 52222-40-9
• Molecular Formula: C₇H₁₂N₄S
• Molecular Weight: 184.265
• European Community (EC) Number: 868-413-6
• Mol file: 52222-40-9.mol

Synonyms:52222-40-9;N4,N4-Dimethyl-2-(methylthio)pyrimidine-4,6-diamine;(6-amino-2-methylthiopyrimidin-4-yl)dimethylamine;4-N,4-N-dimethyl-2-methylsulfanylpyrimidine-4,6-diamine;SCHEMBL9413906;N-[6-amino-2-(methylsulfanyl)pyrimidin-4-yl]-N,N-dimethylamine;AKOS006277720;SB56903;CS-0256700;EN300-651167;AB-323/25048542;Z1198159482;N4,N4-dimethyl-2-(methylsulfanyl)pyrimidine-4,6-diamine

Chemical Property of (6-Amino-2-methylthiopyrimidin-4-yl)dimethylamine

Chemical Property:

• XLogP3: 1.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 2
• Exact Mass: 184.07826757
• Heavy Atom Count: 12
• Complexity: 141

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CN(C)C1=NC(=NC(=C1)N)SC

Technology Process of (6-Amino-2-methylthiopyrimidin-4-yl)dimethylamine

There total 2 articles about (6-Amino-2-methylthiopyrimidin-4-yl)dimethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

4-amino-6-chloro-2-methylthiopyrimidine (1005-38-5) + dimethyl amine (124-40-3) → N4,N4-dimethyl-2-methylsulfanyl-pyrimidine-4,6-diyldiamine (52222-40-9)

Guidance literature:

In methanol; at 80 ℃; for 18h;

Reference yield:

6-amino-2-methylsulfanylpyrimidin-4(3H)-one (1074-41-5) → N4,N4-dimethyl-2-methylsulfanyl-pyrimidine-4,6-diyldiamine (52222-40-9)

Guidance literature:

Multi-step reaction with 2 steps

1: N,N-dimethyl-aniline; POCl₃

2: water

With water; N,N-dimethyl-aniline; trichlorophosphate;

DOI:10.1021/jo01369a024

Reference yield:

N4,N4-dimethyl-2-methylsulfanyl-pyrimidine-4,6-diyldiamine (52222-40-9) → C57H60N9O8S3(1+)*Cl(1-)

Guidance literature:

Multi-step reaction with 3 steps

2: 2.) NaSH

3: dimethylformamide / 1 h / Ambient temperature

With sodium hydrogensulfide; In N,N-dimethyl-formamide;

DOI:10.1021/jm00048a018

upstream raw materials:

4-amino-6-chloro-2-methylthiopyrimidine

dimethyl amine

6-amino-2-methylsulfanylpyrimidin-4(3H)-one