N-(4-heptylphenyl)acetamide

Base Information

• Chemical Name: N-(4-heptylphenyl)acetamide
• CAS No.: 20330-65-8
• Molecular Formula: C₁₅H₂₃NO
• Molecular Weight: 233.354
• Mol file: 20330-65-8.mol

Synonyms:

Chemical Property of N-(4-heptylphenyl)acetamide

Chemical Property:

Purity/Quality:

N-(4-HEPTYLPHENYL)ACETAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4-heptylphenyl)acetamide

There total 10 articles about N-(4-heptylphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-heptylaniline (37529-27-4) + acetyl chloride (75-36-5) → N-(4-heptylphenyl)acetamide (20330-65-8)

Guidance literature:

With pyridine; for 1h; Ambient temperature;

DOI:10.1021/jo00279a040

Reference yield: 12.0%

1-hexene (592-41-6,25067-06-5) + 4-Acetamido-1-iodobenzene (622-50-4) → N-(4-hexylphenyl)acetamide (20330-59-0) + N-(4-heptylphenyl)acetamide (20330-65-8) + N-(4-octylphenyl)acetamide (37593-11-6) + N-(4-nonylphenyl)acetamide (37593-12-7) + N-(4-decylphenyl)acetamide (37593-13-8) + N-(4-butylphenyl)acetamide (3663-20-5) + N-(4-pentylphenyl)acetamide (20330-52-3) + N-(4-undecylphenyl)acetamide (102707-88-0) + N-acetyl-4-n-dodecylaniline (3663-30-7) + N-(4-tridecylphenyl)acetamide (68777-64-0) + N-(4-tetradecylphenyl)acetamide (72755-62-5)

Guidance literature:

1-hexene; With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; at 70 ℃; for 12h; Inert atmosphere; Sealed tube;

With Schwartz's reagent; In tetrahydrofuran; at 50 ℃; for 5h; Inert atmosphere; Sealed tube;

4-Acetamido-1-iodobenzene; With 4,4'-di-tert-butyl-2,2'-bipyridine nickel(II) bromide; tetrabutylammonium p-toluenesulfonate; In tetrahydrofuran; at 20 ℃; for 24h; Inert atmosphere; Irradiation; Sealed tube;

DOI:10.1016/j.chempr.2019.12.010

Reference yield:

1-Heptyne (628-71-7) → N-(4-heptylphenyl)acetamide (20330-65-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 92 percent / triethylamine, Pd⁽⁰⁾(PPh₃)4, Cu₂Br₂ / 0.17 h / Heating

2: 75 percent / H₂ / 5percent Pd/C / ethanol

3: 100 percent / pyridine / 1 h / Ambient temperature

With pyridine; copper(I) bromide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen; triethylamine; palladium on activated charcoal; In ethanol;

DOI:10.1021/jo00279a040

upstream raw materials:

4-heptylaniline

acetyl chloride

1-Heptyne

3,4-dibromonitrobenzene