Technology Process of (S)-(1,4-diphenyl-1,4-dihydropyridin-3-yl)(phenyl)methanone
There total 3 articles about (S)-(1,4-diphenyl-1,4-dihydropyridin-3-yl)(phenyl)methanone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
1-phenyl-3-(phenylamino)prop-2-en-1-one; 3-phenyl-propenal;
With
(2S)-2-{diphenyl[(trimethylsilyl)oxy]methyl}pyrrolidine; benzoic acid;
In
ethyl acetate;
at 0 ℃;
for 96h;
With
chloro-trimethyl-silane; sodium sulfate;
at 20 ℃;
for 24h;
Overall yield = 51 %;
DOI:10.1039/c2cc35644a
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: toluene / Reflux
2.1: (2S)-2-{diphenyl[(trimethylsilyl)oxy]methyl}pyrrolidine; benzoic acid / ethyl acetate / 96 h / 0 °C
2.2: 24 h / 20 °C
With
(2S)-2-{diphenyl[(trimethylsilyl)oxy]methyl}pyrrolidine; benzoic acid;
In
ethyl acetate; toluene;
DOI:10.1039/c2cc35644a
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: toluene / Reflux
2.1: (2S)-2-{diphenyl[(trimethylsilyl)oxy]methyl}pyrrolidine; benzoic acid / ethyl acetate / 96 h / 0 °C
2.2: 24 h / 20 °C
With
(2S)-2-{diphenyl[(trimethylsilyl)oxy]methyl}pyrrolidine; benzoic acid;
In
ethyl acetate; toluene;
DOI:10.1039/c2cc35644a