2-(5-phenyl-3-(pyridyn-2-yl)-1H-pyrazol-1-yl)ethanol

Base Information

• Chemical Name: 2-(5-phenyl-3-(pyridyn-2-yl)-1H-pyrazol-1-yl)ethanol
• CAS No.: 944163-00-2
• Molecular Formula: C₁₆H₁₅N₃O
• Molecular Weight: 265.315
• Mol file: 944163-00-2.mol

Synonyms:

Chemical Property of 2-(5-phenyl-3-(pyridyn-2-yl)-1H-pyrazol-1-yl)ethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(5-phenyl-3-(pyridyn-2-yl)-1H-pyrazol-1-yl)ethanol

There total 1 articles about 2-(5-phenyl-3-(pyridyn-2-yl)-1H-pyrazol-1-yl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

1-phenyl-3-pyridin-2-yl-propane-1,3-dione (10472-94-3) + 2-hydroxyethylhydrazine (109-84-2) → 2-(5-phenyl-3-(pyridyn-2-yl)-1H-pyrazol-1-yl)ethanol (944163-00-2) + 2-(3-phenyl-5-(pyridyn-2-yl)-1H-pyrazol-1-yl)ethanol (1270942-18-1)

Guidance literature:

In ethanol; at 0 - 20 ℃; for 5h;

DOI:10.1016/j.ica.2010.11.041

Reference yield: 78.0%

silver tetrafluoroborate (14104-20-2) + bis(η3-allyl-μ-chloropalladium(II)) + 2-(5-phenyl-3-(pyridyn-2-yl)-1H-pyrazol-1-yl)ethanol (944163-00-2) → (η3-allyl)(2-(5-phenyl-3-(pyridin-2-yl)pyrazol-1-yl)ethanol)palladium(II) tetrafluoroborate (944162-98-5)

Guidance literature:

In dichloromethane; under N2, protected from light; ligand added to mixt. of AgBF4 and Pd complex in dry CH2Cl2 at 0°C; stirred at room temp. for 1.5 h; MeOH added; filtered through Celite; filtrate stirred for 1 h; most of solvent removed under vac.; Et2O added dropwise; filtered; solid rinsed with Et2O; dried under vac.; elem. anal.;

DOI:10.1021/om070093u

Reference yield: 56.0%

bis(acetonitrile)dichloroplatinum(II) (13869-38-0,21264-32-4,13869-42-6) + 2-(5-phenyl-3-(pyridyn-2-yl)-1H-pyrazol-1-yl)ethanol (944163-00-2) → (2-(5-phenyl-3-(pyridin-2-yl)-1H-pyrazol-1-yl)ethanol)dichloridoplatinum(II) (1270942-13-6)

Guidance literature:

In acetonitrile; (N2), 1 equiv. of ligand dissolved in dry CH3CN added to soln. of Pd complex in dry CH3CN, stirred and refluxed for 24 h; concd.(vac.), filtered, washed twice (Et2O), dried (vac.), elem. anal.;

DOI:10.1016/j.ica.2010.11.041

upstream raw materials:

1-phenyl-3-pyridin-2-yl-propane-1,3-dione

2-hydroxyethylhydrazine

Downstream raw materials:

(η3-allyl)(2-(5-phenyl-3-(pyridin-2-yl)pyrazol-1-yl)ethanol)palladium(II) tetrafluoroborate

(2-(5-phenyl-3-(pyridin-2-yl)-1H-pyrazol-1-yl)ethanol)dichloridoplatinum(II)

(2-(5-phenyl-3-(pyridin-2-yl)-1H-pyrazol-1-yl)ethanol)dichloridozinc(II)