(S)-tert-butyl 2-(6-(4'-(2-((S)-1-((S)-2-(methoxycarbonylamino)-3-methylbutanoyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)biphenyl-4-yl)-1H-benzo[d]imidazol-2-yl)pyrrolidine-1-carboxylate

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Chemical Name:(S)-tert-butyl 2-(6-(4'-(2-((S)-1-((S)-2-(methoxycarbonylamino)-3-methylbutanoyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)biphenyl-4-yl)-1H-benzo[d]imidazol-2-yl)pyrrolidine-1-carboxylate
CAS No.:1378383-13-1
Molecular Formula:C₄₂H₄₉N₇O₅
Molecular Weight:731.895
Hs Code.:

(S)-tert-butyl 2-(6-(4'-(2-((S)-1-((S)-2-(methoxycarbonylamino)-3-methylbutanoyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)biphenyl-4-yl)-1H-benzo[d]imidazol-2-yl)pyrrolidine-1-carboxylate

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Chemical Property of (S)-tert-butyl 2-(6-(4'-(2-((S)-1-((S)-2-(methoxycarbonylamino)-3-methylbutanoyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)biphenyl-4-yl)-1H-benzo[d]imidazol-2-yl)pyrrolidine-1-carboxylate

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Technology Process of (S)-tert-butyl 2-(6-(4'-(2-((S)-1-((S)-2-(methoxycarbonylamino)-3-methylbutanoyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)biphenyl-4-yl)-1H-benzo[d]imidazol-2-yl)pyrrolidine-1-carboxylate

There total 5 articles about (S)-tert-butyl 2-(6-(4'-(2-((S)-1-((S)-2-(methoxycarbonylamino)-3-methylbutanoyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)biphenyl-4-yl)-1H-benzo[d]imidazol-2-yl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1679-18-1
4-Chlorophenylboronic acid

: 1378383-13-1
(S)-tert-butyl 2-(6-(4'-(2-((S)-1-((S)-2-(methoxycarbonylamino)-3-methylbutanoyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)biphenyl-4-yl)-1H-benzo[d]imidazol-2-yl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / N,N-dimethyl-formamide; water / 3 h / 75 °C / Inert atmosphere

2: potassium acetate / tris-(dibenzylideneacetone)dipalladium(0); dicyclohexylphosphino-2′,4′,6′-triisopropylbiphenyl / 1,4-dioxane / 0.5 h / 85 °C / Inert atmosphere

3: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 14 h / 85 °C / Inert atmosphere

4: potassium carbonate; hydrogen / palladium 10% on activated carbon / ethanol; water / 18 h / Inert atmosphere

5: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h / 20 °C

With hydrogen; potassium acetate; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dicyclohexylphosphino-2′,4′,6′-triisopropylbiphenyl; palladium 10% on activated carbon; In 1,4-dioxane; 1,2-dimethoxyethane; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 1007882-39-4
(S)-benzyl 2-(5-(4-bromophenyl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

: 1378383-13-1
(S)-tert-butyl 2-(6-(4'-(2-((S)-1-((S)-2-(methoxycarbonylamino)-3-methylbutanoyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)biphenyl-4-yl)-1H-benzo[d]imidazol-2-yl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / N,N-dimethyl-formamide; water / 3 h / 75 °C / Inert atmosphere

2: potassium acetate / tris-(dibenzylideneacetone)dipalladium(0); dicyclohexylphosphino-2′,4′,6′-triisopropylbiphenyl / 1,4-dioxane / 0.5 h / 85 °C / Inert atmosphere

3: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 14 h / 85 °C / Inert atmosphere

4: potassium carbonate; hydrogen / palladium 10% on activated carbon / ethanol; water / 18 h / Inert atmosphere

5: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h / 20 °C

With hydrogen; potassium acetate; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dicyclohexylphosphino-2′,4′,6′-triisopropylbiphenyl; palladium 10% on activated carbon; In 1,4-dioxane; 1,2-dimethoxyethane; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 1378383-07-3
(S)-benzyl 2-(5-(4'-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)biphenyl-4-yl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

: 1378383-13-1
(S)-tert-butyl 2-(6-(4'-(2-((S)-1-((S)-2-(methoxycarbonylamino)-3-methylbutanoyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)biphenyl-4-yl)-1H-benzo[d]imidazol-2-yl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate; hydrogen / palladium 10% on activated carbon / ethanol; water / 18 h / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h / 20 °C

With hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; palladium 10% on activated carbon; In ethanol; water; N,N-dimethyl-formamide;