(S)-benzyl 2-(5-(4-chlorobiphenyl-4-yl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

Base Information

Chemical Name:(S)-benzyl 2-(5-(4-chlorobiphenyl-4-yl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate
CAS No.:1378383-02-8
Molecular Formula:C₂₇H₂₄ClN₃O₂
Molecular Weight:457.959
Hs Code.:

Synonyms:(S)-benzyl 2-(5-(4-chlorobiphenyl-4-yl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

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Chemical Property of (S)-benzyl 2-(5-(4-chlorobiphenyl-4-yl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

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Technology Process of (S)-benzyl 2-(5-(4-chlorobiphenyl-4-yl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

There total 1 articles about (S)-benzyl 2-(5-(4-chlorobiphenyl-4-yl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1007882-39-4
(S)-benzyl 2-(5-(4-bromophenyl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

: 1679-18-1
4-Chlorophenylboronic acid

: 1378383-02-8
(S)-benzyl 2-(5-(4-chlorobiphenyl-4-yl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

Guidance literature:: With potassium carbonate; In water; N,N-dimethyl-formamide; at 75 ℃; for 3h; Inert atmosphere;

Reference yield: 89.0%

: 1378383-02-8
(S)-benzyl 2-(5-(4-chlorobiphenyl-4-yl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

: 73183-34-3
bis(pinacol)diborane

: 1378383-05-1
(S)-benzyl 2-(5-(4'-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)biphenyl-4-yl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

Guidance literature:: With potassium acetate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dicyclohexylphosphino-2′,4′,6′-triisopropylbiphenyl; In 1,4-dioxane; at 85 ℃; for 0.5h; Inert atmosphere;

Reference yield:

: 1378383-02-8
(S)-benzyl 2-(5-(4-chlorobiphenyl-4-yl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

: 1378383-07-3
(S)-benzyl 2-(5-(4'-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)biphenyl-4-yl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium acetate / tris-(dibenzylideneacetone)dipalladium(0); dicyclohexylphosphino-2′,4′,6′-triisopropylbiphenyl / 1,4-dioxane / 0.5 h / 85 °C / Inert atmosphere

2: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 14 h / 85 °C / Inert atmosphere

With potassium acetate; potassium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dicyclohexylphosphino-2′,4′,6′-triisopropylbiphenyl; In 1,4-dioxane; 1,2-dimethoxyethane; water;