Technology Process of N-[[4-[(1-isopropyl-4-piperidyl)sulfinyl]phenyl]methyl]furo[2,3-c]pyridine-2-carboxamide
There total 8 articles about N-[[4-[(1-isopropyl-4-piperidyl)sulfinyl]phenyl]methyl]furo[2,3-c]pyridine-2-carboxamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
In
N,N-dimethyl-formamide;
at 25 ℃;
for 12h;
DOI:10.1016/j.bmcl.2014.12.026
- Guidance literature:
-
Multi-step reaction with 2 steps
1: hydrogen / methanol / 0.5 h / 25 °C
2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide / 12 h / 25 °C
With
hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
In
methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2014.12.026
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 16 h / 25 °C
2.1: dihydrogen peroxide; sulfuric acid; isopropyl alcohol / water; dichloromethane / 2 h / 50 °C
3.1: zinc(II) cyanide; tris-(dibenzylideneacetone)dipalladium(0); 1,1'-bis-(diphenylphosphino)ferrocene / N,N-dimethyl-formamide / 2 h / 100 °C
4.1: thionyl chloride / methanol / 0.5 h / 0 - 25 °C
5.1: titanium(IV) isopropylate; acetic acid / ethanol / 2 h / 60 °C
5.2: 1 h / 60 °C
6.1: hydrogen / methanol / 0.5 h / 25 °C
7.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide / 12 h / 25 °C
With
titanium(IV) isopropylate; zinc(II) cyanide; 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0); thionyl chloride; sulfuric acid; hydrogen; dihydrogen peroxide; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; isopropyl alcohol; diethylazodicarboxylate;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2014.12.026
