N-methyl-1-phenyl-1-methylacetamide

Base Information

• Chemical Name: N-methyl-1-phenyl-1-methylacetamide
• CAS No.: 13490-93-2
• Molecular Formula: C₁₀H₁₃NO
• Molecular Weight: 163.219
• Mol file: 13490-93-2.mol

Synonyms:

Chemical Property of N-methyl-1-phenyl-1-methylacetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-methyl-1-phenyl-1-methylacetamide

There total 13 articles about N-methyl-1-phenyl-1-methylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

methanol (67-56-1) + Benzeneacetamide (103-81-1) → N-methyl-1-phenyl-1-methylacetamide (13490-93-2,58265-30-8) + 2-phenylpropanamide (1125-70-8)

Guidance literature:

With C₅₄H₄₃ClN₃P₂Ru⁽¹⁺⁾*F₆P^(1-); caesium carbonate; In toluene; at 140 ℃; for 12h; Inert atmosphere; Sealed tube; Green chemistry;

DOI:10.1021/acs.orglett.9b01925

Reference yield: 82.0%

methanol (67-56-1) + Benzeneacetamide (103-81-1) → N-methyl-1-phenyl-1-methylacetamide (13490-93-2,58265-30-8)

Guidance literature:

With C₅₄H₄₃ClN₃P₂Ru⁽¹⁺⁾*F₆P^(1-); caesium carbonate; In toluene; at 150 ℃; for 48h; Inert atmosphere; Sealed tube; Green chemistry;

DOI:10.1021/acs.orglett.9b01925

Reference yield: 78.0%

methanol (67-56-1) + 2-phenylpropanal oxime (59647-78-8) → N-methyl-1-phenyl-1-methylacetamide (13490-93-2,58265-30-8)

Guidance literature:

With C₅₄H₄₃ClN₃P₂Ru⁽¹⁺⁾*F₆P^(1-); caesium carbonate; In toluene; at 150 ℃; for 48h; Inert atmosphere; Schlenk technique; Green chemistry;

DOI:10.1002/adsc.201900962

upstream raw materials:

2-phenylpropionyl chloride

methylamine

3,5-dimethyl-4-phenyl-4,5-dihydro-3H-[1,2,3]triazol-4-ol

3-acetyl-1-phenyl-1-methyl-4-(methylamino)-3-penten-2-one

Downstream raw materials:

phenpromethamine