(R)-N-trifluoroacetylaspartic acid-1-methyl ester

Base Information

• Chemical Name: (R)-N-trifluoroacetylaspartic acid-1-methyl ester
• CAS No.: 945984-91-8
• Molecular Formula: C₇H₈F₃NO₅
• Molecular Weight: 243.139
• Mol file: 945984-91-8.mol

Synonyms:

Chemical Property of (R)-N-trifluoroacetylaspartic acid-1-methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-N-trifluoroacetylaspartic acid-1-methyl ester

There total 2 articles about (R)-N-trifluoroacetylaspartic acid-1-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + nyuzenamide B + trifluoroacetic anhydride (407-25-0) → N-trifluoroacetyl-(S)-valine methyl ester (1463-21-4) + N-trifluoroacetyl-(2S)-proline methyl ester (715-58-2) + N-TFA-D-Leu-OMe (81083-98-9) + N-Trifluormethyl-threonin-methylester (88494-53-5) + (R)-N-trifluoroacetylaspartic acid-1-methyl ester (945984-91-8)

Guidance literature:

nyuzenamide B; With hydrogenchloride; In water; at 105 ℃; Inert atmosphere;

methanol; With hydrogenchloride; In water; at 100 ℃; for 0.5h; Inert atmosphere;

trifluoroacetic anhydride; In dichloromethane; at 100 ℃; for 0.0833333h;

DOI:10.1021/acs.orglett.1c00210

Reference yield:

methanol (67-56-1) + nyuzenamide A + trifluoroacetic anhydride (407-25-0) → N-trifluoroacetyl-(S)-valine methyl ester (1463-21-4) + N-trifluoroacetyl-(2S)-proline methyl ester (715-58-2) + N-TFA-D-Leu-OMe (81083-98-9) + N-Trifluormethyl-threonin-methylester (88494-53-5) + (R)-N-trifluoroacetylaspartic acid-1-methyl ester (945984-91-8)

Guidance literature:

nyuzenamide A; With hydrogenchloride; In water; at 105 ℃; Inert atmosphere;

methanol; With hydrogenchloride; In water; at 100 ℃; for 0.5h; Inert atmosphere;

trifluoroacetic anhydride; In dichloromethane; at 100 ℃; for 0.0833333h;

DOI:10.1021/acs.orglett.1c00210

upstream raw materials:

methanol

trifluoroacetic anhydride