2,2,2-trichloro-1-(2-methoxyphenyl)ethanol

Base Information

• Chemical Name: 2,2,2-trichloro-1-(2-methoxyphenyl)ethanol
• CAS No.: 58369-59-8
• Molecular Formula: C9H9 Cl3 O2
• Molecular Weight: 255.528
• Mol file: 58369-59-8.mol

Synonyms:1,1,1-Trichloro-2-hydroxy-2-(2-methoxyphenyl)ethane;2,2,2-Trichloro-1-(2-methoxyphenyl)ethanol; 2-Methoxy-a-(trichloromethyl)benzenemethanol

Chemical Property of 2,2,2-trichloro-1-(2-methoxyphenyl)ethanol

Chemical Property:

• Vapor Pressure: 2.98E-05mmHg at 25°C
• Boiling Point: 342°C at 760 mmHg
• Flash Point: 160.6°C
• Density: 1.429g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,2,2-trichloro-1-(2-methoxyphenyl)ethanol

There total 9 articles about 2,2,2-trichloro-1-(2-methoxyphenyl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

chloroform (67-66-3,8013-54-5) + ortho-anisaldehyde (135-02-4) → 2-methoxy-α-(trichloromethyl)benzyl alcohol (58369-59-8)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; for 6h;

DOI:10.1021/jo000584n

Reference yield: 91.0%

tetrachloromethane (56-23-5) + ortho-anisaldehyde (135-02-4) → 2-methoxy-α-(trichloromethyl)benzyl alcohol (58369-59-8)

Guidance literature:

In chloroform; N,N-dimethyl-formamide; cathodic reduction;

DOI:10.1016/S0040-4039(00)87171-3

Reference yield: 88.0%

tris(2-methoxyphenyl)-1,3,5,2,4,6-trioxatriborinane (79422-01-8) + chloral hydrate (302-17-0) → 2-methoxy-α-(trichloromethyl)benzyl alcohol (58369-59-8)

Guidance literature:

With C₆₂H₇₄Cl₂N₄Pd₂S₂; potassium carbonate; In toluene; at 100 ℃; for 2h; Inert atmosphere; Sealed tube;

DOI:10.1039/d1ra02403e

upstream raw materials:

chloral

4-methoxyphenyl magnesium bromide

ortho-anisaldehyde

2-bromoanisole

Downstream raw materials:

2,2-dichloro-1-(2-methoxyphenyl)-ethan-1-one

ethyl [2,2,2-trichloro-1-(2-methoxyphenyl)ethyl]carbonate

2,2,2-trichloro-1-(4-chlorophenyl)ethanone

2,2-dichloro-1-(4-chlorophenyl)ethanone