4-Hexenoic acid, methyl ester, (4E)-

Base Information

• Chemical Name: 4-Hexenoic acid, methyl ester, (4E)-
• CAS No.: 14017-81-3
• Molecular Formula: C7H12O2
• Molecular Weight: 128.171
• Mol file: 14017-81-3.mol

Synonyms:Methyl (4E)-hex-4-enoate;4-Hexenoic acid, methyl ester, (E)- (8CI);Methyl trans-4-hexenoate;

Chemical Property of 4-Hexenoic acid, methyl ester, (4E)-

Chemical Property:

• Boiling Point: 126 °C at 760 mmHg
• Flash Point: 40.1 °C
• Density: 0.907 g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Hexenoic acid, methyl ester, (4E)-

There total 3 articles about 4-Hexenoic acid, methyl ester, (4E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methylthiophene-5-carboxylic acid (1918-79-2) → (2E,4E)-methylhexa-2,4-dienoate (689-89-4) + Methyl 2,5-Dihydro-5-methyl-2-thiophenecarboxylate (71624-92-5) + methyl (E)-hex-3-enoate (13894-61-6) + methyl (E)-hex-4-enoate (14017-81-3) + methyl (Z)-hex-3-enoate (13894-62-7) + Methyl (Z)-5-Mercapto-3-hexenoate (86610-45-9)

Guidance literature:

With methanol; sulfuric acid; ammonia; lithium; Product distribution; Mechanism; 1) -78 degC, 60 min, 2) room temp., 24 h; other amount of Li: 10 eq.;

DOI:10.1021/jo00167a013

Reference yield:

methanol (67-56-1) + carbon dioxide (124-38-9,18923-20-1) → methyl (2E)-2-methyl-2-pentenoate (1567-14-2) + methyl (E)-hex-3-enoate (13894-61-6) + methyl (E)-hex-4-enoate (14017-81-3)

Guidance literature:

With hydrogenchloride; Yield given. Multistep reaction. Yields of byproduct given; 1.) 3 d, 35 deg C, THF;

DOI:10.1016/0022-328X(87)85007-6

Reference yield:

hex-4-enoic acid (35194-36-6) + methyl iodide (74-88-4) → methyl (E)-hex-4-enoate (14017-81-3) + methyl (Z)-hex-4-enoate (13894-60-5)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 2h; Title compound not separated from byproducts;

DOI:10.1021/ol036062m

upstream raw materials:

2-methylthiophene-5-carboxylic acid

methanol

carbon dioxide

hex-4-enoic acid