7-Ethyl Adenine

Base Information

• Chemical Name: 7-Ethyl Adenine
• CAS No.: 24309-36-2
• Molecular Formula: C₇H₉N₅
• Molecular Weight: 163.182
• Mol file: 24309-36-2.mol

Synonyms:Adenine,7-ethyl- (7CI,8CI); 7-Ethyladenine

Chemical Property of 7-Ethyl Adenine

Chemical Property:

• Vapor Pressure: 4.79E-06mmHg at 25°C
• Melting Point: 237-240 °C
• Boiling Point: 382.2°C at 760 mmHg
• PKA: 4.71±0.30(Predicted)
• Flash Point: 185°C
• PSA: 69.62000
• Density: 1.49g/cm³
• LogP: 1.00960
• Storage Temp.: Refrigerator
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

7-EthylAdenine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 7-Ethyl Adenine is used in the preparation of alkyl bromoadenine derivatives as A2A and A2B receptor antagonists. Its a derivative of Adenine (A280480), widespread throughout animal and plant tissues combined with niacinamide, d-ribose, and phosphoric acids; a constituent of nucleic acids and coenzymes, such as codehydrase I and II, adenylic acid, coalaninedehydrase. It is used in microbial determination of niacin; in research on heredity, virus diseases, and cancer.

Technology Process of 7-Ethyl Adenine

There total 1 articles about 7-Ethyl Adenine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl iodide (75-03-6) + 7H-purin-6-ylamine (73-24-5,71660-29-2,71660-30-5) → 9-ethyladenine (2715-68-6) + N7-Ethyladenine (24309-36-2) + 3-ethyl-3H-purin-6-ylamine (43003-87-8)

Guidance literature:

With sodium hydride; Yield given. Multistep reaction. Yields of byproduct given; 1.) DMF, 30 deg C, 1 h, 2.) DMF, 16 h;

Reference yield:

N7-Ethyladenine (24309-36-2) → 1-Benzyloxy-7-ethyl-1,7-dihydro-purin-6-ylideneamine; hydrobromide

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) m-chloroperoxybenzoic acid / methanol / 72 h / Ambient temperature

2: 96 percent / N,N-dimethyl-acetamide / 0.75 h / Ambient temperature

With 3-chloro-benzenecarboperoxoic acid; In methanol; N,N-dimethyl acetamide;

DOI:10.1248/cpb.44.594

Reference yield:

N7-Ethyladenine (24309-36-2) → 7-Ethyl-1-methoxy-1,7-dihydro-purin-6-ylideneamine; hydriodide

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) m-chloroperoxybenzoic acid / methanol / 72 h / Ambient temperature

2: 90 percent / N,N-dimethyl-acetamide / 4.5 h / Ambient temperature

With 3-chloro-benzenecarboperoxoic acid; In methanol; N,N-dimethyl acetamide;

DOI:10.1248/cpb.44.594

upstream raw materials:

ethyl iodide

7H-purin-6-ylamine