methyl N-(3-nitro-2-pyridyl)-α-alaninate

Base Information

• Chemical Name: methyl N-(3-nitro-2-pyridyl)-α-alaninate
• CAS No.: 146294-95-3
• Molecular Formula: C₉H₁₁N₃O₄
• Molecular Weight: 225.204
• Mol file: 146294-95-3.mol

Synonyms:

Chemical Property of methyl N-(3-nitro-2-pyridyl)-α-alaninate

Chemical Property:

• Boiling Point: 350.6±32.0 °C(Predicted)
• Density: 1.345±0.06 g/cm3(Predicted)

Purity/Quality:

98%min ^*data from raw suppliers

methyl2-[(3-nitropyridin-2-yl)amino]propanoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl N-(3-nitro-2-pyridyl)-α-alaninate

There total 5 articles about methyl N-(3-nitro-2-pyridyl)-α-alaninate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

methanol (67-56-1) + 2-amino-3-nitropyridine (4214-75-9) + 2-oxopropanal (78-98-8) → methyl N-(3-nitro-2-pyridyl)-α-alaninate (146294-95-3)

Guidance literature:

With perchloric acid; In water; for 48h; Heating;

Reference yield:

2-Chloro-3-nitropyridine (5470-18-8,34515-82-7) + ethanol (64-17-5) + methyl 2-aminopropanoate monohydrochloride (13515-97-4) → methyl N-(3-nitro-2-pyridyl)-α-alaninate (146294-95-3) + ethyl 2-(3-nitro-2-pyridyl)aminopropionate

Guidance literature:

With triethylamine; for 4h; Overall yield = 19 g; Reflux;

Reference yield:

2-amino-3-nitropyridine (4214-75-9) → methyl N-(3-nitro-2-pyridyl)-α-alaninate (146294-95-3)

Guidance literature:

Multi-step reaction with 2 steps

1: BF₃ / CH₂Cl₂

2: 65percent HClO₄ / H₂O / 48 h / Heating

With perchloric acid; boron trifluoride; In dichloromethane; water;

upstream raw materials:

methanol

3-hydroxy-2-methyl-8-nitroimidazol<1,2-a>pyridine

2-amino-3-nitropyridine

2-oxopropanal

Refernces

• 1、 -. "HETEROCYCLIC COMPOUND". Paragraph 0416; 0417. . Retrieved 2015/05/26.