Tos-PEG9-t-butyl ester

Base Information

Chemical Name:Tos-PEG9-t-butyl ester
CAS No.:1345337-28-1
Molecular Formula:C₃₀H₅₂O₁₃S
Molecular Weight:652.801
Hs Code.:
Mol file:1345337-28-1.mol

Synonyms:

Suppliers and Price of Tos-PEG9-t-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

BroadPharm
Tos-PEG9-t-butylester 98%
500 MG
$ 540.00

Acrotein
Tos-PEG8-CH2CH2COOtBu 97%
0.25g
$ 183.34

Absolute Chiral
tert-butyl1-(tosyloxy)-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-oate 95%
250 mg
$ 348.00

Total 2 raw suppliers

Chemical Property of Tos-PEG9-t-butyl ester

Chemical Property:

Boiling Point:677.8±55.0 °C(Predicted)
Density:1.142±0.06 g/cm3(Predicted)
Solubility.:Soluble in DMSO, DCM, DMF

Purity/Quality:

>96.00% ^*data from raw suppliers

Tos-PEG9-t-butylester 98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Description Tos-PEG9-t-butyl ester is a PEG linker containing a t-butyl ester and a tosyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The t-butyl protected carboxyl group can be deprotected under acidic conditions. The tosyl group is a very good leaving group for nucleophilic substitution reactions.

Technology Process of Tos-PEG9-t-butyl ester

There total 4 articles about Tos-PEG9-t-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1334177-84-2
tert-butyl 1-hydroxy-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-oate

: 98-59-9
p-toluenesulfonyl chloride

: 1345337-28-1
C₃₀H₅₂O₁₃S

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 24h; Inert atmosphere;
DOI:10.1039/c4nj00654b

Reference yield: 70.0%

: tert-butyl 1-hydroxy-3,6,9,12,15,18,21-heptaoxatetracosan-24-oate

: 98-59-9
p-toluenesulfonyl chloride

: 1345337-28-1
C₃₀H₅₂O₁₃S

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 40h;

Reference yield:

: 5117-19-1
octaethylene glycol

: 1345337-28-1
C₃₀H₅₂O₁₃S

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium / dichloromethane / 1 h / 20 °C

1.2: 12 h / 20 °C

2.1: triethylamine / dichloromethane / 12 h / 30 °C

With sodium; triethylamine; In dichloromethane;