diphenhydramine hydrochloride

Base Information

Chemical Name:diphenhydramine hydrochloride
CAS No.:8052-21-9
Molecular Formula:C₁₇H₂₂NO*Cl
Molecular Weight:291.821
Hs Code.:

Synonyms:

Suppliers and Price of diphenhydramine hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 6 raw suppliers

Chemical Property of diphenhydramine hydrochloride

Chemical Property:

Water Solubility.:1000 g/L

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes: Xn:Harmful;
Statements: R22:;

MSDS Files:

Useful:

Technology Process of diphenhydramine hydrochloride

There total 9 articles about diphenhydramine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 58-73-1
2-diphenylmethoxy-N,N-dimethylethanamine

: 147-24-0,8052-21-9
diphenhydramine hydrochloride

Guidance literature:: With hydrogenchloride; In ethanol; at 20 ℃; for 1h; Time;

Reference yield:

: 108-01-0
2-(N,N-dimethylamino)ethanol

: 776-74-9
Bromodiphenylmethane

: 147-24-0,8052-21-9
diphenhydramine hydrochloride

Guidance literature:: 2-(N,N-dimethylamino)ethanol; Bromodiphenylmethane; In toluene; for 20h; Reflux;

With hydrogenchloride; In diethyl ether; at 25 ℃;
DOI:10.1126/science.aav2211

Reference yield:

: 108-86-1,52753-63-6
bromobenzene

: 147-24-0,8052-21-9
diphenhydramine hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: magnesium / 0.67 h / Reflux; Inert atmosphere

1.2: 5 h / Reflux; Inert atmosphere

2.1: toluene / 4 h / Reflux

3.1: toluene / 20 h / Reflux

3.2: 25 °C

With magnesium; In toluene; 3.1: |Williamson Ether Synthesis;
DOI:10.1126/science.aav2211