2S-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-5-hexynoic acid

Base Information

Chemical Name:2S-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-5-hexynoic acid
CAS No.:1234692-66-0
Molecular Formula:C₂₁H₁₉NO₄
Molecular Weight:349.386
Hs Code.:

Synonyms:

Suppliers and Price of 2S-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-5-hexynoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

ChemPep
Fmoc-D-HomoGly(Propargyl)-OH
1g
$ 1212.00

Activate Scientific
(2R)-2-(Fmoc-amino)-5-hexynoic acid 95% ee
1 g
$ 967.00

Acrotein
(2R)-2-(Fmoc-amino)-5-hexynoicacid 97%
0.1g
$ 150.33

ACHEMBLOCK
(2R)-2-(Fmoc-amino)-5-hexynoicacid 95%
250MG
$ 370.00

ACHEMBLOCK
(2R)-2-(Fmoc-amino)-5-hexynoicacid 95%
100MG
$ 180.00

Total 8 raw suppliers

Chemical Property of 2S-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-5-hexynoic acid

Chemical Property:

Purity/Quality:

99%, ^*data from raw suppliers

Fmoc-D-HomoGly(Propargyl)-OH ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2S-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-5-hexynoic acid

There total 3 articles about 2S-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-5-hexynoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 28920-43-6
(fluorenylmethoxy)carbonyl chloride

: (S)-2-[bis(tert-butoxycarbonylamino)]-hex-5-ynoic acid tert-butyl ester

: 942518-21-0,1234692-66-0
2S-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-5-hexynoic acid

Guidance literature:: (S)-2-[bis(tert-butoxycarbonylamino)]-hex-5-ynoic acid tert-butyl ester; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3h; Inert atmosphere;

With hydrogenchloride; Inert atmosphere;

(fluorenylmethoxy)carbonyl chloride; at 20 ℃; for 4h; Inert atmosphere;
DOI:10.1021/acs.joc.1c03027

Reference yield:

: 102774-86-7
9-fluorenylmethyl N-succinimidyl carbonate

: 98891-36-2
(S)-2-amino-5-hexynoic acid

: 942518-21-0,1234692-66-0
2S-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-5-hexynoic acid

Guidance literature:: (S)-2-amino-5-hexynoic acid; With edetate disodium; sodium carbonate; In water; for 0.166667h; pH=9 - 10;

9-fluorenylmethyl N-succinimidyl carbonate; In water; acetonitrile; at -10 - 20 ℃; for 15h;
DOI:10.1016/j.tetlet.2017.05.007

Reference yield:

: 38771-21-0
4-bromobut-1-yne

: 82911-69-1
N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

: 942518-21-0,1234692-66-0
2S-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-5-hexynoic acid

Guidance literature:: 4-bromobut-1-yne; With Gly-Ni-(S)-2-[N-(N-benzylpropyl)amino]benzophenone; sodium hydroxide; In N,N-dimethyl-formamide; at 20 ℃; for 0.1h; Inert atmosphere;

With hydrogenchloride; In methanol; at 60 ℃; for 0.5h;

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide; With sodium carbonate; In 1,4-dioxane; at 0 - 20 ℃;
DOI:10.1021/jm201125d