FMOC Aminotriester

Base Information

• Chemical Name: FMOC Aminotriester
• CAS No.: 1217553-84-8
• Molecular Formula: C₃₇H₅₁NO₈
• Molecular Weight: 637.814
• Mol file: 1217553-84-8.mol

Synonyms:

Chemical Property of FMOC Aminotriester

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

FMOCAminotriester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of FMOC Aminotriester

There total 3 articles about FMOC Aminotriester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(fluorenylmethoxy)carbonyl chloride (28920-43-6) + 4-amino-4-(2-tert-butoxycarbonylethyl)heptanedioic acid di-tertbutyl ester (136586-99-7) → 4-(2-tert-butoxycarbonyl-ethyl)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-heptanedioic acid di-tert-butyl ester (1217553-84-8)

Guidance literature:

With sodium carbonate; In 1,4-dioxane; water; at 0 - 20 ℃; for 2h;

Reference yield: 96.0%

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide (82911-69-1) + 4-amino-4-(2-tert-butoxycarbonylethyl)heptanedioic acid di-tertbutyl ester (136586-99-7) → 4-(2-tert-butoxycarbonyl-ethyl)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-heptanedioic acid di-tert-butyl ester (1217553-84-8)

Guidance literature:

In tetrahydrofuran; at 20 ℃;

DOI:10.1021/ja106076h

Reference yield:

di-tert-butyl 4-<2-(tert-butoxycarbonyl)ethyl>-4-nitroheptanedicarboxylate (136587-00-3) → 4-(2-tert-butoxycarbonyl-ethyl)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-heptanedioic acid di-tert-butyl ester (1217553-84-8)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen / ethanol / 20 °C

2: tetrahydrofuran / 20 °C

With hydrogen; In tetrahydrofuran; ethanol;

DOI:10.1021/ja106076h

upstream raw materials:

(fluorenylmethoxy)carbonyl chloride

4-amino-4-(2-tert-butoxycarbonylethyl)heptanedioic acid di-tertbutyl ester

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

di-tert-butyl 4-<2-(tert-butoxycarbonyl)ethyl>-4-nitroheptanedicarboxylate