methyl 3-amino-4-ethoxybenzoate

Base Information

• Chemical Name: methyl 3-amino-4-ethoxybenzoate
• CAS No.: 927802-54-8
• Molecular Formula: C₁₀H₁₃NO₃
• Molecular Weight: 195.218
• Mol file: 927802-54-8.mol

Synonyms:

Chemical Property of methyl 3-amino-4-ethoxybenzoate

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

MethylEster3-Amino-4-ethoxybenzoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Methyl Ester 3-Amino-4-ethoxybenzoic Acid was used in the study of structure-based design and synthesis of inhibitors targeting HDAC8. It was also used for preparation of Neratinib (N390090), which is an antitumor agent.

Technology Process of methyl 3-amino-4-ethoxybenzoate

There total 6 articles about methyl 3-amino-4-ethoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(ethoxy)benzoic acid (619-86-3) → methyl 3-amino-4-ethoxybenzoate (927802-54-8)

Guidance literature:

Multi-step reaction with 3 steps

1: thionyl chloride / 1 h / 0 °C / Reflux

2: nitric acid; sulfuric acid / 0.5 h / 0 - 50 °C

3: hydrogenchloride; iron / methanol; water / 1 h / Reflux

With hydrogenchloride; thionyl chloride; sulfuric acid; nitric acid; iron; In methanol; water;

DOI:10.1021/acs.jmedchem.5b01478

Reference yield:

methyl 4-ethoxybenzoate (23676-08-6) → methyl 3-amino-4-ethoxybenzoate (927802-54-8)

Guidance literature:

Multi-step reaction with 2 steps

1: nitric acid; sulfuric acid / 0.5 h / 0 - 50 °C

2: hydrogenchloride; iron / methanol; water / 1 h / Reflux

With hydrogenchloride; sulfuric acid; nitric acid; iron; In methanol; water;

DOI:10.1021/acs.jmedchem.5b01478

Reference yield:

methyl 4-ethoxy-3-nitrobenzoate → methyl 3-amino-4-ethoxybenzoate (927802-54-8)

Guidance literature:

With hydrogenchloride; iron; In methanol; water; for 1h; Reflux;

DOI:10.1021/acs.jmedchem.5b01478

upstream raw materials:

ethyl bromide

methyl 3-amino-4-hydroxybenzoate

methanol

3-amino-4-ethoxybenzoic acid

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