16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione 17,21-dipropionate

Base Information

Chemical Name:16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione 17,21-dipropionate
CAS No.:71868-53-6
Molecular Formula:C₂₈H₃₈O₇
Molecular Weight:486.606
Hs Code.:

Synonyms:

Suppliers and Price of 16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione 17,21-dipropionate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
11β,17,21-Trihydroxy-16α-methylpregna-1,4-diene-3,20-dione17,21-Dipropionate
10mg
$ 970.00

Sigma-Aldrich
Alclometasone dipropionate Related Compound A United States Pharmacopeia (USP) Reference Standard
20mg
$ 1160.00

Total 6 raw suppliers

Chemical Property of 16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione 17,21-dipropionate

Chemical Property:

Purity/Quality:

> 95% ^*data from raw suppliers

11β,17,21-Trihydroxy-16α-methylpregna-1,4-diene-3,20-dione17,21-Dipropionate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses 11β,17,21-Trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 17,21-Dipropionate is an impurity in the synthesis of Alclometasone-17,21-dipropionate (A514580), a synthetic glucocorticoid steroid used for inflammatory skin conditions.

Technology Process of 16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione 17,21-dipropionate

There total 2 articles about 16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione 17,21-dipropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 10417-63-7
16α-Methyl-11β,17α,21-trihydroxy-pregna-1,4-diene-3,20-dione

: 71868-53-6
16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione 17,21-dipropionate

Guidance literature:: Multi-step reaction with 2 steps

1: TsOH*H₂O / dimethylsulfoxide / 2 h / Ambient temperature

2: 1.) aq. AcOH, 2.) pyridine / 1.) RT, 1 h, 2.) RT, 3.5 h

With pyridine; toluene-4-sulfonic acid; acetic acid; In dimethyl sulfoxide;
DOI:10.1021/jm00178a015