(E)-4-ethoxy-2'-methylthiostilbene

Base Information

• Chemical Name: (E)-4-ethoxy-2'-methylthiostilbene
• CAS No.: 81580-99-6
• Molecular Formula: C₁₇H₁₈OS
• Molecular Weight: 270.395
• Mol file: 81580-99-6.mol

Synonyms:

Chemical Property of (E)-4-ethoxy-2'-methylthiostilbene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-4-ethoxy-2'-methylthiostilbene

There total 4 articles about (E)-4-ethoxy-2'-methylthiostilbene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

methoxybenzene (100-66-3) + Phenetole (103-73-1) + Benzo[b]thiophene (95-15-8,11095-43-5) → 2,3-dihydro-2-(p-methoxyphenyl)benzothiophen (81580-86-1) + 2-methylthio-4′-methoxy-trans-stilbene (81580-97-4) + 2,3-dihydro-3-(p-methoxyphenyl)benzothiophen (81580-87-2) + (E)-4-ethoxy-2'-methylthiostilbene (81580-99-6)

Guidance literature:

With aluminium trichloride; at 20 ℃; Further byproducts given;

Reference yield:

2-(methylthio)benzyl alcohol (33384-77-9) → (E)-4-ethoxy-2'-methylthiostilbene (81580-99-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 83 percent / conc. hydrochloric acid / 1 h / Ambient temperature

2: 1.) triethyl phosphite, 2.) sodium methoxide

With hydrogenchloride; sodium methylate; triethyl phosphite;

Reference yield:

1-chloromethyl-2-methylsulfanylbenzene (26190-68-1) + 4-ethoxybenzaldehyde (10031-82-0) → (E)-4-ethoxy-2'-methylthiostilbene (81580-99-6)

Guidance literature:

With sodium methylate; triethyl phosphite; Multistep reaction;

upstream raw materials:

1-chloromethyl-2-methylsulfanylbenzene

4-ethoxybenzaldehyde

methoxybenzene

Phenetole