Benzyl 2-(dibenzylamino)acetate

Base Information

• Chemical Name: Benzyl 2-(dibenzylamino)acetate
• CAS No.: 141483-49-0
• Molecular Formula: C23H23NO2
• Molecular Weight: 345.441
• European Community (EC) Number: 683-424-4
• Nikkaji Number: J859.444I
• Mol file: 141483-49-0.mol

Synonyms:Benzyl 2-(dibenzylamino)acetate;141483-49-0;Glycine, N,N-bis(phenylmethyl)-, phenylmethyl ester;DIBENZYLAMINO-ACETIC ACID BENZYL ESTER;Benzyl2-(dibenzylamino)acetate;SCHEMBL7571319;CGUUNCXYRZIRJH-UHFFFAOYSA-N;N,N-dibenzyl-glycine benzyl ester;AKOS024322375;SB83334

Chemical Property of Benzyl 2-(dibenzylamino)acetate

Chemical Property:

• PSA: 29.54000
• LogP: 4.43220
• XLogP3: 4.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 9
• Exact Mass: 345.172878976
• Heavy Atom Count: 26
• Complexity: 373

Purity/Quality:

95% ^*data from raw suppliers

Benzyl2-(dibenzylamino)acetate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C(C=C1)CN(CC2=CC=CC=C2)CC(=O)OCC3=CC=CC=C3

Technology Process of Benzyl 2-(dibenzylamino)acetate

There total 3 articles about Benzyl 2-(dibenzylamino)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

benzyl bromide (100-39-0) + glycine (56-40-6,18875-39-3,25718-94-9) → N,N-dibenzyl-glycine benzyl ester (141483-49-0)

Guidance literature:

With potassium carbonate; In water; at 100 ℃; for 15h;

DOI:10.1002/jlcr.868

Reference yield: 64.0%

methanol (67-56-1) + benzyl bromide (100-39-0) + glycine (56-40-6,18875-39-3,25718-94-9) → (dibenzylamino)acetic acid methyl ester (94226-55-8) + N,N-dibenzyl-glycine benzyl ester (141483-49-0)

Guidance literature:

With potassium carbonate; In water; for 3h; Heating;

DOI:10.1016/S0957-4166(03)00371-9

Reference yield:

glycine (56-40-6,18875-39-3,25718-94-9) → N,N-dibenzyl-glycine benzyl ester (141483-49-0)

Guidance literature:

DOI:10.1021/jo0263622

upstream raw materials:

benzyl bromide

glycine

methanol

Downstream raw materials:

N,N-dibenzyl-2-aminoethanol

dimethyl 3-(N,N-dibenzylamino)-2-oxopropylphosphonate

2-N,N-Dibenzylaminoacetaldehyde

(E)-4-dibenzylamino-2-[2-13C]buten-1-ol

Refernces

• 1、 Takatori, Kazuhiko,Hayashi, Akira,Kajiwara, Masahiro. "Asymmetric synthesis of L-[4-13C]lysine by alkylation of oxazinone derivative as a chiral glycine equivalent". . p. 787 - 795. Retrieved 2007/10/03.
• 2、 Ordonez, Mario,Gonzalez-Morales, Angelina,Ruiz, Cesar,De La Cruz-Cordero, Ricardo,Fernandez-Zertuche, Mario. "Preparation of (R)- and (S)-γ-amino-β-hydroxypropylphosphonic acid from glycine". . p. 1775 - 1779. Retrieved 2007/10/03.