N-(4-phenyl-1,3-thiazol-2-yl)benzamide

Base Information

• Chemical Name: N-(4-phenyl-1,3-thiazol-2-yl)benzamide
• CAS No.: 14269-45-5
• Molecular Formula: C16H12N2OS
• Molecular Weight: 280.35
• DSSTox Substance ID: DTXSID10353610
• Nikkaji Number: J1.266.303J
• Wikidata: Q82131303
• ChEMBL ID: CHEMBL60334
• Mol file: 14269-45-5.mol

Synonyms:N-(4-phenyl-1,3-thiazol-2-yl)benzamide;14269-45-5;N-(4-Phenyl-thiazol-2-yl)-benzamide;Benzamide, N-(4-phenyl-2-thiazolyl)-;CHEMBL60334;Enamine_004302;Cambridge id 5149845;Oprea1_007140;Oprea1_016303;Oprea1_462006;CBDivE_004384;SCHEMBL1270375;SCHEMBL18874193;DTXSID10353610;HMS1406D12;BDBM50101790;STK337540;STK972349;AKOS000478692;AKOS002233837;NCGC00262409-01;AB00074536-01;EN300-18081371;Z27772118;N-[(2Z)-4-phenyl-1,3-thiazol-2(3H)-ylidene]benzamide

Chemical Property of N-(4-phenyl-1,3-thiazol-2-yl)benzamide

Chemical Property:

• XLogP3: 3.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 280.06703418
• Heavy Atom Count: 20
• Complexity: 324

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=CSC(=N2)NC(=O)C3=CC=CC=C3

Technology Process of N-(4-phenyl-1,3-thiazol-2-yl)benzamide

There total 9 articles about N-(4-phenyl-1,3-thiazol-2-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

2-Amino-4-phenylthiazole (2010-06-2) + benzoyl chloride (98-88-4) → 2-[(benzoyl)amino]-4-(phenyl)thiazole (14269-45-5)

Guidance literature:

In pyridine; Ambient temperature;

Reference yield: 84.0%

2-Amino-4-phenylthiazole (2010-06-2) + benzoic acid (65-85-0,8013-63-6) → 2-[(benzoyl)amino]-4-(phenyl)thiazole (14269-45-5)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 24h;

DOI:10.1016/j.ejmech.2013.11.020

Reference yield: 70.0%

2-amino-4-phenyl-thiazole hydrobromide (34161-31-4) + benzoyl chloride (98-88-4) → 2-[(benzoyl)amino]-4-(phenyl)thiazole (14269-45-5)

Guidance literature:

With triethylamine; In 1,4-dioxane; Heating;

DOI:10.1016/S0960-894X(01)00356-0

upstream raw materials:

2-Amino-4-phenylthiazole

benzoyl chloride

benzoic acid anhydride

thiourea

Downstream raw materials:

N-(4-phenylthiazole-2-yl)phenylimidoyl chloride

N-(3-methyl-4-phenylthiazol-2(3H)-ylidene)benzamide

N-methyl-N-(4-phenyl-thiazol-2-yl)-benzamide

2-phenyl-5-phenylthiazolo-<3,2-b>-s-triazole