FMoc-DL-proline

Base Information

• Chemical Name: FMoc-DL-proline
• CAS No.: 144829-96-9
• Molecular Formula: C20H19NO4
• Molecular Weight: 337.375
• Mol file: 144829-96-9.mol

Synonyms:Fmoc-D-Pro-OH;N-Fmoc-D-proline;Fmoc-D-proline;Fmoc-DL-proline;Fmoc-DPro-OH;Fmoc-D-proline-OH;Fmoc-Proline-OH;

Chemical Property of FMoc-DL-proline

Chemical Property:

• PSA: 66.84000
• LogP: 3.42240

Purity/Quality:

97% ^*data from raw suppliers

1-[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]PYRROLIDINE-2-CARBOXYLIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of FMoc-DL-proline

There total 3 articles about FMoc-DL-proline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide (82911-69-1) + rac-Pro-OH (609-36-9,25191-13-3,37159-97-0,4305-67-3,4607-28-7) → 1-(((9H-fluoren-9-yl)methoxy)carbonyl)pyrrolidine-2-carboxylic acid (144829-96-9)

Guidance literature:

rac-Pro-OH; With sodium carbonate; In water; at 20 ℃; for 0.0833333h;

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield:

(fluorenylmethoxy)carbonyl chloride (28920-43-6) + 1.3-chlorobromopropane (109-70-6) → 1-(((9H-fluoren-9-yl)methoxy)carbonyl)pyrrolidine-2-carboxylic acid (144829-96-9)

Guidance literature:

Multistep reaction;

DOI:10.1016/j.tetlet.2003.09.119

Reference yield:

→ 1-(((9H-fluoren-9-yl)methoxy)carbonyl)pyrrolidine-2-carboxylic acid (144829-96-9)

Guidance literature:

upstream raw materials:

(fluorenylmethoxy)carbonyl chloride

1.3-chlorobromopropane

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

rac-Pro-OH

Downstream raw materials:

Ava-Phe-Phe-D-Pro-Leu-Met-NH₂

(S)-2-{[(R)-1-((S)-2-{[(2R,3R,4R,5S,6R)-3-((S)-2-Amino-propionylamino)-4,5-bis-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-carbonyl]-amino}-propionyl)-pyrrolidine-2-carbonyl]-amino}-propionic acid

(R)-(9H-fluorene-9-yl)methyl 2-(chlorocarbonyl)pyrrolidine-1-carboxylate