METHYL 5-PHENYL-2-THIOPHENECARBOXYLATE

Base Information

• Chemical Name: METHYL 5-PHENYL-2-THIOPHENECARBOXYLATE
• CAS No.: 14597-62-7
• Molecular Formula: C12H10O2S
• Molecular Weight: 218.276
• Mol file: 14597-62-7.mol

Synonyms:5-phenyl-thiophene-2-carboxylic acid methyl ester;2-methoxycarbonyl-5-phenylthiophene;methyl 5-phenylthiophene-2-carboxylate;5-Phenyl-thiophen-2-carbonsaeure-methylester;METHYL 5-PHENYL-2-THIOPHENECARBOXYLATE;

Chemical Property of METHYL 5-PHENYL-2-THIOPHENECARBOXYLATE

Chemical Property:

• Melting Point: 96-98 °C(Solv: methanol (67-56-1))
• Boiling Point: 352.1±30.0 °C(Predicted)
• PSA: 54.54000
• Density: 1.198±0.06 g/cm3(Predicted)
• LogP: 3.20170

Purity/Quality:

99% ^*data from raw suppliers

Methyl 5-phenylthiophene-2-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL 5-PHENYL-2-THIOPHENECARBOXYLATE

There total 22 articles about METHYL 5-PHENYL-2-THIOPHENECARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

5-bromo-2-thiophenecarboxylic acid methyl ester (62224-19-5) + phenylboronic acid (98-80-6) → 5-phenylthiophene-2-carboxylic acid methyl ester (14597-62-7)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,4-dioxane; at 90 ℃; Inert atmosphere;

DOI:10.1002/cmdc.201000475

Reference yield: 90.0%

2-phenylthiophene (825-55-8) + carbon dioxide (124-38-9,18923-20-1) + methyl iodide (74-88-4) → 5-phenylthiophene-2-carboxylic acid methyl ester (14597-62-7)

Guidance literature:

2-phenylthiophene; carbon dioxide; With 18-crown-6 ether; cesium fluoride; lithium tert-butoxide; at 180 ℃; for 15h; under 760.051 Torr; Inert atmosphere; Sealed tube;

methyl iodide; at 60 ℃; for 2h;

DOI:10.1002/chem.201805926

Reference yield: 84.0%

methanol (67-56-1) + 5-phenyl-2-thiophenecarboxylic acid (19163-24-7) → 5-phenylthiophene-2-carboxylic acid methyl ester (14597-62-7)

Guidance literature:

With sulfuric acid; for 0.5h; Heating;

DOI:10.1016/j.bmc.2003.08.009

upstream raw materials:

β-chlorocinnamaldehyde

sodium methylate

ethyl 2-sulfanylacetate

methanol

Downstream raw materials:

5-phenylthiophene-2-carbohydrazide

5-phenyl-2-thiophenecarboxylic acid

5-phenyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene-2-carboxylic acid methyl ester