(R)-1-Hydroxy-1-phenylacetone

Base Information

Chemical Name:(R)-1-Hydroxy-1-phenylacetone
CAS No.:1798-60-3
Molecular Formula:C9H10O2
Molecular Weight:150.177
Hs Code.:2914400090
European Community (EC) Number:217-285-4
UNII:7V3493I8FQ
DSSTox Substance ID:DTXSID601313240
Nikkaji Number:J53.527C
Wikidata:Q27268887
Mol file:1798-60-3.mol

Synonyms:1798-60-3;(R)-1-Hydroxy-1-phenylacetone;(r)-phenylacetylcarbinol;(1R)-1-hydroxy-1-phenylpropan-2-one;Phenylacetylcarbinol, (-)-;(R)-PAC;(R)-1-Hydroxy-1-phenyl-2-propanone;(R)-1-Hydroxy-1-phenylpropan-2-one;L-PAC;(-)-phenylacetylcarbinol;UNII-7V3493I8FQ;(r)-1-hydroxy-1-phenylpropanone;7V3493I8FQ;EINECS 217-285-4;(1R)-1-Hydroxy-1-phenyl-2-propanone;EC 217-285-4;l-phenylacetylcarbinol;rel-(1R)-1-hydroxy-1-phenylpropan-2-one;R-PAC;(R)-Acetylphenylcarbinol;(1r)-phenylacetylcarbinol;SCHEMBL890219;(r)-(-)-phenylacetylcarbinol;CHEBI:149671;ZBFFNPODXBJBPW-VIFPVBQESA-N;DTXSID601313240;D-(-)-PHENYLACETYLCARBINOL;MFCD22414394;AKOS027384464;D-(-)-1-HYDROXY-1-PHENYLPROPANONE;2-Propanone, 1-hydroxy-1-phenyl-, (1R)-;(1R)-1-PHENYL-1-HYDROXYPROPAN-2-ONE;D-(-)-1-PHENYL-1-HYDROXY-2-PROPANONE;EN300-1268487;EN300-6735033;(-)-(1R)-1-HYDROXY-1-PHENYL-2-PROPANONE;(-)-(1R)-1-HYDROXY-1-PHENYLPROPAN-2-ONE;.ALPHA.-ACETYLBENZYL ALCOHOL [USP IMPURITY];Q27268887;EPHEDRINE HYDROCHLORIDE IMPURITY A [EP IMPURITY]

Suppliers and Price of (R)-1-Hydroxy-1-phenylacetone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Medical Isotopes, Inc.
(R)-1-Hydroxy-1-phenylpropanone
10 mg
$ 390.00

Total 85 raw suppliers

Chemical Property of (R)-1-Hydroxy-1-phenylacetone

Chemical Property:

Vapor Pressure:0.01mmHg at 25°C
Refractive Index:1.539
Boiling Point:253.343 °C at 760 mmHg
PKA:12.33±0.20(Predicted)
Flash Point:104.584 °C
PSA：37.30000
Density:1.12 g/cm³
LogP:1.30900
Storage Temp.:-20°C Freezer, Under inert atmosphere
Solubility.:Chloroform (Slightly), Ethanol (Sparingly), Ethyl Acetate (Slightly), Methanol (
XLogP3:1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:150.068079557
Heavy Atom Count:11
Complexity:137

Purity/Quality:

99%, ^*data from raw suppliers

(R)-1-Hydroxy-1-phenylpropanone ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=O)C(C1=CC=CC=C1)O
Isomeric SMILES:CC(=O)[C@@H](C1=CC=CC=C1)O
General Description (R)-1-Hydroxy-1-phenylacetone is a chiral ketone produced as an intermediate in the enantioselective hydrogenation of 1-phenyl-1,2-propanedione. It is the major product when the carbonyl group adjacent to the phenyl ring is selectively reduced, often yielding the (R)-enantiomer with moderate to high enantiomeric excess (up to 64% ee) when using chiral modifiers like cinchonidine or Pt-based catalysts under optimized conditions (e.g., in dichloromethane at low temperatures and moderate H₂ pressure). (R)-1-hydroxy-1-phenylacetone is also referred to as (R)-phenylacetylcarbinol and serves as a precursor in asymmetric synthesis.

Technology Process of (R)-1-Hydroxy-1-phenylacetone

There total 60 articles about (R)-1-Hydroxy-1-phenylacetone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.6%

: 100-52-7
benzaldehyde

: 127-17-3
2-oxo-propionic acid

: 1798-60-3
(R)-1-hydroxy-1-phenyl-2-propanone

Guidance literature:: With glutathione S-transferase fused with Escherichia coli acetohydroxy acid synthase I; thiamine pyrophosphate; magnesium chloride; D,L-dithiothreitol; In aq. phosphate buffer; dimethyl sulfoxide; at 30 ℃; for 1.33333h; pH=7; pH-value; Temperature; Solvent; enantioselective reaction; Catalytic behavior; Enzymatic reaction;
DOI:10.1039/c7ra04641c