(4-(2-Hydroxyethoxy)phenyl)(phenyl)methanone

Base Information

• Chemical Name: (4-(2-Hydroxyethoxy)phenyl)(phenyl)methanone
• CAS No.: 14814-17-6
• Molecular Formula: C15H14O3
• Molecular Weight: 242.274
• European Community (EC) Number: 810-808-2
• DSSTox Substance ID: DTXSID10933315
• Nikkaji Number: J864.930H
• Wikidata: Q82909129
• ChEMBL ID: CHEMBL74930
• Mol file: 14814-17-6.mol

Synonyms:(4-(2-Hydroxyethoxy)phenyl)(phenyl)methanone;14814-17-6;4-(2-Hydroxyethoxy)benzophenone;[4-(2-hydroxyethoxy)phenyl]-phenylmethanone;Methanone, [4-(2-hydroxyethoxy)phenyl]phenyl-;[4-(2-hydroxyethoxy)phenyl](phenyl)methanone;Methanone, (4-(2-hydroxyethoxy)phenyl)phenyl-;Oprea1_326139;Oprea1_466844;MLS000712218;CHEMBL74930;SCHEMBL887049;DTXSID10933315;4-(2-hydroxyethoxy)-benzophenone;PNTLMFABGCHLMN-UHFFFAOYSA-N;2-(4-benzoylphenoxyl)ethan-1-ol;HMS2667D18;Benzophenone, 4-(2-hydroxyethoxy)-;MFCD00623913;STK370940;AKOS000522129;DS-19713;SMR000281985;CS-0162295;(4-(2-Hydroxyethoxyl)phenyl)(phenyl)methanone;4-(2-hydroxyethoxy) phenyl (phenyl) methanone;C72819;{4-[(2-Hydroxyethyl)oxy]phenyl}(phenyl)methanone;A911326;SR-01000357310;SR-01000357310-1

Chemical Property of (4-(2-Hydroxyethoxy)phenyl)(phenyl)methanone

Chemical Property:

• Melting Point: 79-80 °C(Solv: heptane (142-82-5))
• Boiling Point: 421.0±25.0 °C(Predicted)
• PKA: 14.14±0.10(Predicted)
• PSA: 46.53000
• Density: 1.178±0.06 g/cm3(Predicted)
• LogP: 2.28870
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: Chloroform, Dichloromethane, DMSO, Methanol
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 242.094294304
• Heavy Atom Count: 18
• Complexity: 251

Purity/Quality:

99.9% ^*data from raw suppliers

(4-(2-Hydroxyethoxy)phenyl)(phenyl)methanone 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(=O)C2=CC=C(C=C2)OCCO
• Uses: [4-(2-Hydroxyethoxy)phenyl]phenylmethanone is an intermediate in the synthesis of E-Ospemifene (O703005). E-Ospemifene is the E-isomer of Ospemifene (O703000) and is useful for lowering serum cholesterol. It acts as an anti-atherosclerotic and is also estrogen-like.

Technology Process of (4-(2-Hydroxyethoxy)phenyl)(phenyl)methanone

There total 13 articles about (4-(2-Hydroxyethoxy)phenyl)(phenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

[1,3]-dioxolan-2-one (96-49-1) + 4-Hydroxybenzophenone (1137-42-4) → (4-(2-hydroxyethoxy)phenyl)(phenyl)methanone (14814-17-6)

Guidance literature:

With sodium iodide; In toluene; at 60 ℃; for 1.5h; Reflux;

Reference yield: 91.0%

1-acetoxy-2-(4-benzoylphenoxy)ethane (75230-42-1) → (4-(2-hydroxyethoxy)phenyl)(phenyl)methanone (14814-17-6)

Guidance literature:

With sodium hydroxide; In water; Heating;

Reference yield: 86.0%

4-Hydroxybenzophenone (1137-42-4) + 2-bromoethanol (540-51-2) → (4-(2-hydroxyethoxy)phenyl)(phenyl)methanone (14814-17-6)

Guidance literature:

With potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; at 65 ℃;

DOI:10.1039/c2sm26879e

upstream raw materials:

4-Hydroxybenzophenone

2-chloro-ethanol

1-acetoxy-2-(4-benzoylphenoxy)ethane

2-(4-benzoylphenoxy)ethyl tetrahydro-2H-pyran-2-yl ether

Downstream raw materials:

methyl 6-hydroxy-2-(4-(2-hydroxyethoxy)phenyl)-2-phenyl-2H-naphtho[1,2-b]pyran-5-carboxylate

methyl 6-(2-bromo-2-methylpropanoyloxy)-2-(4-(2-(2-bromo-2-methylpropanoyloxy)ethoxy)phenyl)-2-phenyl-2H-naphtho[1,2-b]pyran-5-carboxylate

1-(4-(2-hydroxyethoxy)phenyl)-1-phenylprop-2-yn-1-ol

Refernces

• 1、 Zhang, Ze Ping,Rong, Min Zhi,Zhang, Ming Qiu. "Mechanically Robust, Self-Healable, and Highly Stretchable “Living” Crosslinked Polyurethane Based on a Reversible C?C Bond". . . Retrieved 2018.
• 2、 Xu, Junhuai,Yan, Rui,Wang, Haibo,Du, Zongliang,Gu, Jun,Cheng, Xu,Xiong, Junjie. "A novel biocompatible zwitterionic polyurethane with AIE effect for cell imaging in living cells". . p. 6798 - 6804. Retrieved 2018/02/23.