Benzoic acid, 4-bromo-, 2,2-dimethylhydrazide

Base Information

• Chemical Name: Benzoic acid, 4-bromo-, 2,2-dimethylhydrazide
• CAS No.: 14908-44-2
• Molecular Formula: C9H11BrN2O
• Molecular Weight: 243.103
• Mol file: 14908-44-2.mol

Synonyms:

Chemical Property of Benzoic acid, 4-bromo-, 2,2-dimethylhydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzoic acid, 4-bromo-, 2,2-dimethylhydrazide

There total 4 articles about Benzoic acid, 4-bromo-, 2,2-dimethylhydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

methanol (67-56-1) + 4-bromobenzoic acid hydrazide (5933-32-4) → 1-(4-bromobenzoyl)-2,2-dimethylhydrazine (14908-44-2)

Guidance literature:

With [carbonylchlorohydrido{bis[2-(diphenylphosphinomethyl)ethyl]amino}ethylamino] ruthenium(II); potassium tert-butylate; In toluene; for 48h; chemoselective reaction; Schlenk technique; Inert atmosphere; Heating; Green chemistry;

DOI:10.1021/acs.orglett.0c02369

Reference yield: 77.0%

N,N-Dimethylhydrazine (57-14-7) + 4-chlorobenzoyl chloride (586-75-4) → 1-(4-bromobenzoyl)-2,2-dimethylhydrazine (14908-44-2)

Guidance literature:

In tetrahydrofuran; at 40 ℃;

DOI:10.1023/A:1015028806581 DOI:10.1023/A:1025644620981

Reference yield:

4-methoxycarbonylphenyl bromide (619-42-1) + N,N-Dimethylhydrazine (57-14-7) → 1-(4-bromobenzoyl)-2,2-dimethylhydrazine (14908-44-2)

Guidance literature:

With sodium methylate; In methanol;

DOI:10.1021/jo01266a085

upstream raw materials:

4-methoxycarbonylphenyl bromide

N,N-Dimethylhydrazine

4-chlorobenzoyl chloride

methanol

Refernces

• 1、 Thiyagarajan, Subramanian,Gunanathan, Chidambaram. "Direct Catalytic Symmetrical, Unsymmetrical N,N-Dialkylation and Cyclization of Acylhydrazides Using Alcohols". supporting information. p. 6617 - 6622. Retrieved 2020/09/02.
• 2、 Karnaukhova,Nizovtseva,Nakhmanovich,Albanov,Komarova. "Reactions of 1,3-dibromopropyne with 1-aroyl-2,2-dimethylhydrazines as a new method for the synthesis of substituted 1,3,4-oxadiazinium bromides". . p. 2475 - 2476. Retrieved 2007/10/03.