N-(4-Methoxyphenyl)-N-MethylaMinoacetonitrile

Base Information

• Chemical Name: N-(4-Methoxyphenyl)-N-MethylaMinoacetonitrile
• CAS No.: 149399-58-6
• Molecular Formula: C10H12N2O
• Molecular Weight: 176.218
• Mol file: 149399-58-6.mol

Synonyms:N-cyanomethyl-4-methoxy-N-methylaniline;

Chemical Property of N-(4-Methoxyphenyl)-N-MethylaMinoacetonitrile

Chemical Property:

• Boiling Point: 326.4±27.0 °C(Predicted)
• PKA: 2.41±0.50(Predicted)
• PSA: 36.26000
• Density: 1.092±0.06 g/cm3(Predicted)
• LogP: 1.65498

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(4-Methoxyphenyl)-N-MethylaMinoacetonitrile

There total 9 articles about N-(4-Methoxyphenyl)-N-MethylaMinoacetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

sodium cyanide (773837-37-9) + 4-methoxy-N,N-dimethylanilne (701-56-4) → 2-[(4-methoxyphenyl)(methyl)amino]acetonitrile (149399-58-6)

Guidance literature:

With C₂₂H₂₆N₂O₅U; dihydrogen peroxide; acetic acid; In methanol; at 20 ℃; for 7h; Catalytic behavior; Irradiation;

DOI:10.1016/j.poly.2016.12.033

Reference yield: 87.0%

trimethylsilyl cyanide (7677-24-9) + 4-methoxy-N,N-dimethylanilne (701-56-4) → 2-[(4-methoxyphenyl)(methyl)amino]acetonitrile (149399-58-6)

Guidance literature:

With tert.-butylhydroperoxide; iron(II) chloride; In methanol; decane; at 20 ℃; Inert atmosphere;

DOI:10.1039/b910548d

Reference yield: 87.0%

4-methoxy-N,N-dimethylanilne (701-56-4) + potassium thioacyanate (333-20-0) → 2-[(4-methoxyphenyl)(methyl)amino]acetonitrile (149399-58-6)

Guidance literature:

With tert.-butylhydroperoxide; In water; at 80 ℃; for 1h; Green chemistry;

DOI:10.1021/jo502846c

upstream raw materials:

benzoyl cyanide

4-methoxy-N,N-dimethylanilne

sodium cyanide

sodium cyanide

Refernces

• 1、 Murahashi, Shun-Ichi,Komiya, Naruyoshi,Terai, Hiroyuki,Nakae, Takahiro. "Aerobic Ruthenium-Catalyzed Oxidative Cyanation of Tertiary Amines with Sodium Cyanide". . p. 15312 - 15313. Retrieved 2003.
• 2、 Yuan, Zaifeng,Li, Na,Zhu, Chunyu,Xia, Chengfeng. "Copper-catalyzed synthesis of α-amino nitriles through methyl transfer from DMF to aromatic amines". supporting information. p. 2854 - 2857. Retrieved 2018/03/23.
• 3、 Zhang, Lianpeng,Gu, Xin,Lu, Ping,Wang, Yanguang. "Synthesis of α-aminonitriles via a FeSO4-mediated oxidative cyanation of tertiary amines with benzoyl cyanide and molecular oxygen or TBHP". . p. 2359 - 2363. Retrieved 2016/04/19.