1-(4-Nitrophenyl)-4-phenylpiperazine

Base Information

• Chemical Name: 1-(4-Nitrophenyl)-4-phenylpiperazine
• CAS No.: 14960-95-3
• Molecular Formula: C16H17N3O2
• Molecular Weight: 283.33
• DSSTox Substance ID: DTXSID40398519
• Nikkaji Number: J3.632.724C
• Wikidata: Q82200550
• ChEMBL ID: CHEMBL1333089
• Mol file: 14960-95-3.mol

Synonyms:1-(4-nitrophenyl)-4-phenylpiperazine;MLS001183678;SMR000502845;14960-95-3;CHEMBL1333089;SCHEMBL12952781;DTXSID40398519;HMS2833N07;STK125927;AKOS005062955;1-(4-nitrophenyl)-4-phenyl-piperazine;4,4'-(N-phenyl-1-piperazinyl)-nitrobenzene;J3.632.724C;SR-01000812755;SR-01000812755-2;Z31199331

Chemical Property of 1-(4-Nitrophenyl)-4-phenylpiperazine

Chemical Property:

• XLogP3: 3.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 283.132076794
• Heavy Atom Count: 21
• Complexity: 336

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CN(CCN1C2=CC=CC=C2)C3=CC=C(C=C3)[N+](=O)[O-]

Technology Process of 1-(4-Nitrophenyl)-4-phenylpiperazine

There total 6 articles about 1-(4-Nitrophenyl)-4-phenylpiperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

4-phenyl-1-piperazine (92-54-6) + 4-chlorobenzonitrile (100-00-5) → 1-(4-nitro-phenyl)-4-phenyl-piperazine (14960-95-3)

Guidance literature:

With Aliquat (at)366; potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 24h;

DOI:10.1016/j.bioorg.2014.08.006

Reference yield: 91.0%

4-phenyl-1-piperazine (92-54-6) + 4-Fluoronitrobenzene (350-46-9,178603-76-4) → 1-(4-nitro-phenyl)-4-phenyl-piperazine (14960-95-3)

Guidance literature:

In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.bmcl.2015.01.004

Reference yield: 87.0%

p-nitrobenzene iodide (636-98-6) + 4-phenyl-1-piperazine (92-54-6) → 1-(4-nitro-phenyl)-4-phenyl-piperazine (14960-95-3)

Guidance literature:

With cesium hydroxide; In dimethyl sulfoxide; at 20 ℃; for 3h;

DOI:10.1055/s-2004-830853

upstream raw materials:

4-phenyl-1-piperazine

4-chlorobenzonitrile

4-Fluoronitrobenzene

p-nitrobenzene iodide

Downstream raw materials:

4-(p-Nitrophenyl)-1-(p-nitroazobenzenyl)piperazine

N-(4-formylphenyl)-N'-(4-nitrophenyl)piperazine

[1-(4-Methoxy-phenyl)-meth-(E)-ylidene]-[4-(4-phenyl-piperazin-1-yl)-phenyl]-amine

[1-(2-Methoxy-phenyl)-meth-(E)-ylidene]-[4-(4-phenyl-piperazin-1-yl)-phenyl]-amine

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