(2-Amino-5-chlorophenyl)(cyclopropyl)methanone

Base Information

• Chemical Name: (2-Amino-5-chlorophenyl)(cyclopropyl)methanone
• CAS No.: 150879-49-5
• Molecular Formula: C10H10ClNO
• Molecular Weight: 195.648
• DSSTox Substance ID: DTXSID90431546
• Wikidata: Q82245456
• Mol file: 150879-49-5.mol

Synonyms:150879-49-5;(2-Amino-5-chlorophenyl)(cyclopropyl)methanone;Methanone, (2-amino-5-chlorophenyl)cyclopropyl-;(2-amino-5-chlorophenyl)-cyclopropylmethanone;SCHEMBL2471282;DTXSID90431546;CZBLTZZQGNVTFH-UHFFFAOYSA-N;FT-0765254;4-CHLORO-2-CYCLOPROPANECARBONYLANILINE;(2-amino-5-chlorophenyl)(cyclopropyl)-methanone

Chemical Property of (2-Amino-5-chlorophenyl)(cyclopropyl)methanone

Chemical Property:

• XLogP3: 2.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 195.0450916
• Heavy Atom Count: 13
• Complexity: 215

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC1C(=O)C2=C(C=CC(=C2)Cl)N

Technology Process of (2-Amino-5-chlorophenyl)(cyclopropyl)methanone

There total 4 articles about (2-Amino-5-chlorophenyl)(cyclopropyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

1-(2-Amino-5-chloro-phenyl)-4-chloro-butan-1-one (158875-31-1) → cyclopropyl (4-chloroanilin-2-yl)-ketone (150879-49-5)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; at 25 ℃;

DOI:10.1016/0040-4039(94)85011-9

Reference yield: 83.0%

2-amino-5-chlorobenzonitrile (5922-60-1) + cyclopropylmagnesium bromide (23719-80-4) → cyclopropyl (4-chloroanilin-2-yl)-ketone (150879-49-5)

Guidance literature:

2-amino-5-chlorobenzonitrile; cyclopropylmagnesium bromide; In tetrahydrofuran; at 0 - 80 ℃;

With hydrogenchloride; In tetrahydrofuran; water; at 0 - 20 ℃;

DOI:10.1021/jm900915x

Reference yield: 74.0%

4-chloro-aniline (106-47-8) + cyclopropropanecarbonitrile (5500-21-0) → 1-(2-Amino-5-chloro-phenyl)-4-chloro-butan-1-one (158875-31-1) + cyclopropyl (4-chloroanilin-2-yl)-ketone (150879-49-5)

Guidance literature:

With gallium(III) trichloride; boron trichloride; In chlorobenzene; at 100 ℃; for 20h; Yields of byproduct given;

DOI:10.1016/0040-4039(94)85011-9

upstream raw materials:

4-chloro-aniline

cyclopropropanecarbonitrile

1-(2-Amino-5-chloro-phenyl)-4-chloro-butan-1-one

2-amino-5-chlorobenzonitrile

Downstream raw materials:

6-chloro-4-cyclopropylquinazolin-2(1H)-one

C₁₄H₁₂ClN₃O₂