(-)-Methylphenylpropylphosphine oxide

Base Information

• Chemical Name: (-)-Methylphenylpropylphosphine oxide
• CAS No.: 1515-99-7
• Molecular Formula: C10H15OP
• Molecular Weight: 182.202
• Mol file: 1515-99-7.mol

Synonyms:(S)-(-)-Methyl-n-propyl-phenyl-phosphinoxid;(S)-methylphenylpropylphosphine oxide;methylphenylpropylphosphine oxide;(S)-Methyl-n-propyl-phenyl-phosphinoxid;(S)-(-)-Methylphenylpropyl-phosphinoxid;(S)-methylphenyl-n-propylphosphine oxide;

Chemical Property of (-)-Methylphenylpropylphosphine oxide

Chemical Property:

• PSA: 26.88000
• LogP: 2.71480

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (-)-Methylphenylpropylphosphine oxide

There total 49 articles about (-)-Methylphenylpropylphosphine oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

methyl-phenyl-propyl-phosphine oxide (4653-63-8) + (-)-(2R,3R)-trans-2,3-bis(hydroxydiphenylmethyl)-1,4-dioxaspiro[4.5]decane (114026-76-5,123287-35-4) → (R)-(+)-methylphenyl-n-propylphosphine oxide (17170-48-8) + (S)-(-)-Methylphenyl-n-propylphosphanoxid (1515-99-7) + C10H15OP*2C34H34O4

Guidance literature:

In water; at 50 ℃; for 336h;

DOI:10.1002/ejoc.202000035

Reference yield: 65.7%

methyl magnesium iodide (917-64-6) + (R)-Phenyl-propyl-phosphinic acid (S)-3-bromo-1-methyl-propyl ester (87219-88-3) → (S)-(-)-Methylphenyl-n-propylphosphanoxid (1515-99-7)

Guidance literature:

In diethyl ether; benzene; at 80 ℃; for 33h;

DOI:10.1246/cl.1983.913

Reference yield: 65.0%

ethyl (S)-methyl(phenyl)phosphinate (7301-81-7,34638-79-4,33642-98-7) + n-propylmagnesium bromide (927-77-5) → (S)-(-)-Methylphenyl-n-propylphosphanoxid (1515-99-7)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 12h; enantioselective reaction; Schlenk technique; Inert atmosphere;

DOI:10.1039/d1cc00646k

upstream raw materials:

(+)-(S)-methyl-n-propyl phenylphosphine

(-)-(R)-methyl-n-propylphenylphosphine

methylmagnesium chloride

n-propylmagnesium bromide