2-Propenoic acid,3-[4-(methylsulfonyl)phenyl]-, methyl ester, (2E)-

Base Information

Chemical Name:2-Propenoic acid,3-[4-(methylsulfonyl)phenyl]-, methyl ester, (2E)-
CAS No.:186457-49-8
Molecular Formula:C11H12 O4 S
Molecular Weight:240.28
Hs Code.:

Synonyms:2-Propenoicacid, 3-[4-(methylsulfonyl)phenyl]-, methyl ester, (E)-; AN 20519

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Propenoic acid,3-[4-(methylsulfonyl)phenyl]-, methyl ester, (2E)-

Chemical Property:

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MSDS Files:: SDS file from LookChem

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Technology Process of 2-Propenoic acid,3-[4-(methylsulfonyl)phenyl]-, methyl ester, (2E)-

There total 2 articles about 2-Propenoic acid,3-[4-(methylsulfonyl)phenyl]-, methyl ester, (2E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 67-56-1
methanol

: 5345-30-2,88899-85-8
3-(4-methanesulfonyl-phenyl)-acrylic acid

: 186457-49-8
methyl (2E)-3-[4-(methylsulfonyl)phenyl]acrylate

Guidance literature:: With thionyl chloride; at 20 ℃; Inert atmosphere; Reflux;
DOI:10.1055/s-0031-1289706

Reference yield:

: 5398-77-6
para-methanesulfonylbenzaldehyde

: 186457-49-8
methyl (2E)-3-[4-(methylsulfonyl)phenyl]acrylate

Guidance literature:: Multi-step reaction with 2 steps

1: piperidine; pyridine / 2 h / Inert atmosphere; Reflux

2: thionyl chloride / 20 °C / Inert atmosphere; Reflux

With piperidine; pyridine; thionyl chloride; 1: Knoevenagel condensation;
DOI:10.1055/s-0031-1289706

Reference yield: 52.0%

: 186457-49-8
methyl (2E)-3-[4-(methylsulfonyl)phenyl]acrylate

: 1373543-39-5
methyl (2R,3S)-2,3-dihydroxy-3-[4-(methylsulfonyl)phenyl]propanoate

Guidance literature:: With methanesulfonamide; AD-mix-α; water; In tert-butyl alcohol; at 25 ℃; for 20h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1055/s-0031-1289706