(1S,2S)-1,2-Diphenyl-N,N'-bis[(1R)-1-phenylethyl]ethane-1,2-diamine

Base Information

Chemical Name:(1S,2S)-1,2-Diphenyl-N,N'-bis[(1R)-1-phenylethyl]ethane-1,2-diamine
CAS No.:156730-49-3
Molecular Formula:C30H32N2
Molecular Weight:420.58800
Hs Code.:
DSSTox Substance ID:DTXSID30452831
Nikkaji Number:J1.861.957A
Wikidata:Q82273679
Mol file:156730-49-3.mol

Synonyms:156730-49-3;(1S,2S)-1,2-Diphenyl-N,N'-bis[(1R)-1-phenylethyl]ethane-1,2-diamine;CTK4C9162;DTXSID30452831

Suppliers and Price of (1S,2S)-1,2-Diphenyl-N,N'-bis[(1R)-1-phenylethyl]ethane-1,2-diamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of (1S,2S)-1,2-Diphenyl-N,N'-bis[(1R)-1-phenylethyl]ethane-1,2-diamine

Chemical Property:

PSA：24.06000
LogP:7.95240
XLogP3:6.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:9
Exact Mass:420.256549029
Heavy Atom Count:32
Complexity:449

Purity/Quality:: >95%,>98%e.e. ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C1=CC=CC=C1)NC(C2=CC=CC=C2)C(C3=CC=CC=C3)NC(C)C4=CC=CC=C4
Isomeric SMILES:C[C@H](C1=CC=CC=C1)N[C@@H](C2=CC=CC=C2)[C@H](C3=CC=CC=C3)N[C@H](C)C4=CC=CC=C4

Technology Process of (1S,2S)-1,2-Diphenyl-N,N'-bis[(1R)-1-phenylethyl]ethane-1,2-diamine

There total 4 articles about (1S,2S)-1,2-Diphenyl-N,N'-bis[(1R)-1-phenylethyl]ethane-1,2-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: 100-59-4
phenylmagnesium chloride

: 129171-89-7
1,4-bis<(R)-α-methylbenzyl>-1,4-diaza-1,3-butadiene

: 156730-49-3,314249-68-8
(1S,2S)-1,2-diphenyl-N,N'-bis((R)-1-phenylethyl)ethane-1,2-diamine

Guidance literature:: phenylmagnesium chloride; 1,4-bis<(R)-α-methylbenzyl>-1,4-diaza-1,3-butadiene; In tetrahydrofuran; diethyl ether; at -78 - 0 ℃; for 5.25h; Inert atmosphere;

With acetic acid; In tetrahydrofuran; diethyl ether; at 0 ℃; Inert atmosphere;
DOI:10.1021/op060225f

Reference yield:

: 56941-77-6
(R)-1-phenylethyl(benzylidene)amine

: 314249-68-8
(1R,2R)-1,2-Diphenyl-N,N'-bis-((R)-1-phenyl-ethyl)-ethane-1,2-diamine

: 156730-49-3,314249-68-8
(1S,2S)-1,2-diphenyl-N,N'-bis((R)-1-phenylethyl)ethane-1,2-diamine

: 314249-68-8
(1R,2S)-1,2-Diphenyl-N,N'-bis-((R)-1-phenyl-ethyl)-ethane-1,2-diamine

Guidance literature:: With samarium diiodide; ytterbium(III) triflate; In tetrahydrofuran; at -20 ℃; Yield given. Yields of byproduct given;
DOI:10.1016/S0040-4039(98)00484-5

Reference yield:

: 3886-69-9
(R)-1-phenyl-ethyl-amine

: 156730-49-3,314249-68-8
(1S,2S)-1,2-diphenyl-N,N'-bis((R)-1-phenylethyl)ethane-1,2-diamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: formic acid; sodium sulfate / water; n-heptane / 3.5 h / 33 °C

2.1: tetrahydrofuran; diethyl ether / 5.25 h / -78 - 0 °C / Inert atmosphere

2.2: 0 °C / Inert atmosphere

With formic acid; sodium sulfate; In tetrahydrofuran; diethyl ether; n-heptane; water;
DOI:10.1021/op060225f