56941-77-6

Upstream product

• 100-52-7 benzaldehyde 
• 618-36-0 rac-methylbenzylamine 
• 3480-59-9 N-(1-phenylethyl)benzamide 
• 3287-99-8 benzylamine hydrochloride 
• 538-51-2 benzylidene phenylamine 
• 100-46-9 benzylamine 
• 780-25-6 N-benzylidene benzylamine 
• 100-51-6 benzyl alcohol 
• 2627-86-3 (S)-1-phenyl-ethylamine 
• 591-51-5 phenyllithium 
• 3886-69-9 (R)-1-phenyl-ethyl-amine 
• 38235-77-7 (R)-N-benzyl-1-phenylethylamine 
• 128593-66-8 (R)-N-benzyl-(α-methyl-benzyl)amine hydrochloride 
• 131320-25-7 N-[(R)-2'-hydroxy-1'-phenylethyl]-(R)-1-phenyl-1-ethylamine 

Downstream Products

• 14428-98-9 N-benzyl-N-(1-phenylethylidene)amine 
• 107909-60-4 N-(α-Adamant-1-ylbenzyl)-α-phenylethylamin 
• 107909-60-4 N-(α-Adamant-1-ylbenzyl)-α-phenylethylamin 
• 3893-33-2 benzil monoazine 
• 78846-97-6 (+/-) 1-(α-methylbenzyl)-3,3,4-triphenyl-2-azetidinone 
• 3193-62-2 N-benzyl-1-phenylethylamine 
• 83100-99-6 DL-N-(α-Methylbenzyl)phenylglycinethylester 
• 10040-80-9 phenyl{[1-phenylethyl]amino}acetonitrile 
• 78488-56-9 1,2-Diphenyl-N-(1-phenyl-ethyl)-ethane-1,2-diamine 
• 1212057-36-7 O,O-diphenyl α-[(1-phenylethyl)amino]benzylphosphonate 
• 241819-55-6 1-phenyl-N-(1-phenylethyl)but-3-en-1-amine 
• 30625-73-1 α-Phenylethyl-α-phenylisobutyl-amin 
• 538-51-2 benzylidene phenylamine 
• 780-25-6 N-benzylidene benzylamine 

Relevant academic research and scientific papers

Highly stereoselective synthesis of β-lactams by condensation of the titanium enolate of a chiral 2-pyridylthioester with chiral imines

The reaction of the titanium enolate of a 2-pyridylthioester derived from (R)-3-hydroxybutyric acid with chiral imines affords 3,3'-anti-3,4-trans configurated β-lactams in a highly selective fashion. The methodology has been applied to the synthesis of a

Synthesis method of R-benzyl phenylethylamine

The invention is suitable for the technical field of chemical synthesis, and provides a synthetic method of R-benzyl phenylethylamine, which comprises the following steps: reacting R-benzyl phenylethylamine with benzaldehyde in methanol to obtain an imine substance; and carrying out reduction reaction on the imine substance and sodium borohydride to obtain the R-benzyl phenylethylamine. According to the synthetic method of R-benzyl phenylethylamine provided by the embodiment of the invention, methanol is used as a solvent in the process of synthesizing an intermediate imine from R-benzyl phenylethylamine and benzaldehyde, operation of evaporating toluene after toluene is used as a solvent for reaction in the prior art can be reduced, and the subsequent reduction reaction can continue to use the methanol solvent, so that the cost is reduced, and operation is simplified. In addition, the product synthesized by the synthesis method is high in yield and high in purity.

Vanadium-and chromium-catalyzed dehydrogenative synthesis of imines from alcohols and amines

Vanadium(IV) tetraphenylporphyrin dichloride and chromium(III) tetraphenylporphyrin chloride have been developed as catalysts for the acceptorless dehydrogenation of alcohols. The catalysts have been applied to the direct synthesis of imines in overall good yields from a variety of alcohols and amines. The transformations are proposed to proceed by metal?ligand bifunctional pathways with an outer-sphere transfer of two hydrogen atoms from the alcohol to the metal porphyrin complexes. The results show that vanadium and chromium catalysts can also be employed for the dehydrogenation of alcohols with the release of hydrogen gas, and they may represent valuable alternatives to other catalysts based on Earth-abundant metals.

Identification of N-acyl-N-indanyl-α-phenylglycinamides as selective TRPM8 antagonists designed to mitigate the risk of adverse effects

Transient receptor potential melastatin 8 (TRPM8), a temperature-sensitive ion channel responsible for detecting cold, is an attractive molecular target for the treatment of pain and other disorders. We have previously discovered a selective TRPM8 antagon

Synthesis of limonene β-amino alcohol from (R)-(+)-α-methylbenzylamine and (+)-limonene 1,2-epoxide

Two new compounds of β-amino alcohol are obtained using (R) - (+) - α-methylbenzylamine as starting material which is converted into two amines. Each of these compounds reacted in excess with a 1: 1 mixture of cis and trans-limonene oxide in the presence of water as a catalyst. The products obtained show that β-amino alcohol derived from trans-limonene oxide is obtained and unreacted cis-limonene oxide from the reaction mixture as well as the amine is attained. Whereas the addition of the synthesized carbamate of the same primary amine over the 1: 1 mixture of cis and trans -limonene oxide in the presence of water results in the hydrolysis product and the recovery of unreacted trans-limonene oxide.

Dehydrogenative amide synthesis from alcohols and amines utilizing N-heterocyclic carbene-based ruthenium complexes as efficient catalysts: The influence of catalyst loadings, ancillary and added ligands

The metal-catalyzed dehydrogenative coupling of alcohols and amines to access amides has been recognized as an atom-economic and environmental-friendly process. Apart from the formation of the amide products, three other kinds of compounds (esters, imines and amines) may also be produced. Therefore, it is of vital importance to investigate product distribution in this transformation. Herein, N-heterocyclic carbene-based Ru (NHC/Ru) complexes [Ru-1]-[Ru-5] with different ancillary ligands were prepared and characterized. Based on these complexes, we selected condition A (without an added NHC precursor) and condition B (with an added NHC precursor) to comprehensively explore the selectivity and yield of the desired amides. After careful evaluation of various parameters, the Ru loadings, added NHC precursors and the electronic/steric properties of ancillary NHC ligands were found to have considerable influence on this catalytic process.

Manganese-Catalyzed Selective Hydrogenative Cross-Coupling of Nitriles and Amines to Form Secondary Imines

Manganese complexes with tridentate PNN ligands have been synthesized as catalysts for hydrogenative cross-coupling reaction of nitriles and amines to form secondary imines. This reaction afforded a variety of unsymmetrical secondary imines in good yields with excellent selectivity. Investigation of catalyst intermediates indicated that an amido manganese complex may be the active catalyst species for this reaction. (Figure presented.).

Stereochemical analysis of chiral amines, diamines, and amino alcohols: Practical chiroptical sensing based on dynamic covalent chemistry

Practical chiroptical sensing with a small group of commercially available aromatic aldehydes is demonstrated. Schiff base formation between the electron-deficient 2,4-dinitrobenzaldehyde probe and either primary amines, diamines, or amino alcohols proceeds smoothly in chloroform at room temperature and is completed in the presence of molecular sieves within 2.5 hours. The substrate binding coincides with a distinct circular dichroism signal induction at approximately 330 nm, which can be correlated to the absolute configuration and enantiomeric composition of the analyte. The usefulness of this sensing method is highlighted with the successful sensing of 18 aliphatic and aromatic amines and amino alcohols and five examples showing quantitative %ee determination with good accuracy.

Iridium complexes with a new type of N^N′-donor anionic ligand catalyze the N-benzylation of amines via borrowing hydrogen

The development of efficient and eco-friendly methods for the synthesis of elaborate amines is highly desired as they are valuable chemicals. The catalytic alkylation of amines using alcohols as alkylating agents, through the so-called borrowing hydrogen process, satisfies several of the principles of green chemistry. In this paper, four neutral half-sandwich complexes of Ru(II), Rh(III), and Ir(III) have been synthesized and tested as catalysts in the N-benzylation of amines with benzyl alcohol. The new derivatives contain a N^N′ anionic ligand derived from 5-(pyridin-2-ylmethylene)hydantoin (Hpyhy) that has never been tested in metal complexes with catalytic applications. In particular, the Ir derivatives, [(Cp*)IrX(pyhy)] (X = Cl or H), exhibit high activity along with good selectivity in the process. Indeed, the scope of the optimized protocol has been proved in the benzylation of several primary and secondary amines. The selectivity towards monoalkylated or dialkylated amines has been tuned by adjusting the amine:alcohol ratio and the reaction time. Experimental results support a mechanism consisting of three consecutive steps, two of which are Ir catalyzed, and a favorable condensation step without the assistance of the catalyst. Moreover, an unproductive competitive pathway can operate when the reaction is performed in open-air vessels, due to the irreversible release of H2. This route is hampered when the reaction is carried out in close vessels, likely because the release of H2 is reversed through metal-based heterolytic cleavage. From our viewpoint, these results show the potential of the new catalysts in a very attractive and promising methodology for the synthesis of amines.

A Resin-Bound Peptoid as a Recyclable Heterogeneous Catalyst for Oxidation Reactions

Reusable solid-grafted catalysts have environmental and economical advantages over soluble catalysts. Numerous catalysts, including peptides, were immobilized on solid supports to enable their recyclability. Nevertheless, the few catalytic peptoids – N-substituted glycine oligomers – reported to date were only used off-resin. The soluble peptoids BT and DI, a trimer and dimer having two catalytic side-chains, were developed as bio-inspired oxidation catalysts. BT has an additional structure-directing group, which enables intramolecular cooperativity between the two catalytic groups (“intra-peptoid” mode). Thus, it catalyzes the oxidation of primary alcohols with much higher efficiency than DI. Herein, we present resin-bound BT and DI (TG-BT and TG-DI) as the first insoluble and recyclable catalytic peptoids. We discovered that though TG-BT also operates through the intra-peptoid cooperativity mode, it is less efficient than BT, even after several cycles. On the other hand, TG-DI is far more active than DI and can be recycled several times to enable a much higher turn-over-number. Our studies revealed that TG-DI operates through an intra-resin cooperativity mode, and this enables its high activity compared with DI, BT and TG-BT.