N-Methoxy-N-methyl-1-cyclohexene-1-carboxamide

Base Information

Chemical Name:N-Methoxy-N-methyl-1-cyclohexene-1-carboxamide
CAS No.:158243-49-3
Molecular Formula:C9H15NO2
Molecular Weight:169.224
Hs Code.:
DSSTox Substance ID:DTXSID801245508
Nikkaji Number:J607.853B
Mol file:158243-49-3.mol

Synonyms:N-Methoxy-N-methyl-1-cyclohexene-1-carboxamide;DTXSID801245508;158243-49-3

Suppliers and Price of N-Methoxy-N-methyl-1-cyclohexene-1-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-Methoxy-N-methyl-1-cyclohexene-1-carboxamide

Chemical Property:

XLogP3:1.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:169.110278721
Heavy Atom Count:12
Complexity:199

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CN(C(=O)C1=CCCCC1)OC

Technology Process of N-Methoxy-N-methyl-1-cyclohexene-1-carboxamide

There total 5 articles about N-Methoxy-N-methyl-1-cyclohexene-1-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 17497-53-9
1-iodo-1-cyclohexene

: 201230-82-2
carbon monoxide

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 158243-49-3
N-methyl-N-methoxy-1-cyclohexene-1-carboxamide

Guidance literature:: With palladium diacetate; triethylamine; triphenylphosphine; In N,N-dimethyl-formamide; at 50 ℃; for 85h; under 30003 Torr; chemoselective reaction; Autoclave;
DOI:10.1016/j.tet.2010.04.076

Reference yield: 58.0%

: 201230-82-2
carbon monoxide

: 28075-50-5
cyclohex-1-en-1-yl trifluoromethane sulfonate

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 158243-49-3
N-methyl-N-methoxy-1-cyclohexene-1-carboxamide

Guidance literature:: With sodium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; palladium diacetate; In tetrahydrofuran; at 20 ℃;
DOI:10.1021/jo7024898

Reference yield:

: 636-82-8
cyclohexene-1-carboxylic acid

: 158243-49-3
N-methyl-N-methoxy-1-cyclohexene-1-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2.5 h / 0 - 20 °C / Inert atmosphere

2: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

With oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; In dichloromethane;
DOI:10.1016/j.tetlet.2015.10.039