3',5'-DIFLUORO-4'-HYDROXYPROPIOPHENONE

Base Information

• Chemical Name: 3',5'-DIFLUORO-4'-HYDROXYPROPIOPHENONE
• CAS No.: 178374-78-2
• Molecular Formula: C9H8F2O2
• Molecular Weight: 186.158
• Hs Code.: 2914700090
• Mol file: 178374-78-2.mol

Synonyms:1-(3,5-Difluoro-4-hydroxyphenyl)propan-1-one;3,5-Difluoro-4-hydroxypropiophenone;

Chemical Property of 3',5'-DIFLUORO-4'-HYDROXYPROPIOPHENONE

Chemical Property:

• Appearance/Colour: crystalline powder
• Vapor Pressure: 0.00393mmHg at 25°C
• Melting Point: 126-128 °C
• Refractive Index: 1.504
• Boiling Point: 271.2 °C at 760 mmHg
• PKA: 6.42±0.36(Predicted)
• Flash Point: 117.8 °C
• PSA: 37.30000
• Density: 1.289 g/cm³
• LogP: 2.26310

Purity/Quality:

98%min ^*data from raw suppliers

3'',5''-Difluoro-4''-hydroxypropiophenone ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3',5'-DIFLUORO-4'-HYDROXYPROPIOPHENONE

There total 2 articles about 3',5'-DIFLUORO-4'-HYDROXYPROPIOPHENONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,6-difluorophenyl propionate (171291-49-9) → 3',5'-difluoro-4'-hydroxypropiophenone (178374-78-2)

Guidance literature:

With aluminium trichloride; at 90 - 95 ℃; for 2h;

DOI:10.1016/0957-4166(95)00232-E

Reference yield:

2,6-difluorophenol (28177-48-2) → 3',5'-difluoro-4'-hydroxypropiophenone (178374-78-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 61 percent / acetonitrile / 18 h / Heating

2: AlCl₃ / 2 h / 90 - 95 °C

With aluminium trichloride; In acetonitrile;

DOI:10.1016/0957-4166(95)00232-E

Reference yield: 100.0%

benzyl bromide (100-39-0) + 3',5'-difluoro-4'-hydroxypropiophenone (178374-78-2) → 1-(4-benzyloxy-3,5-difluorophenyl)-propane-1-one

Guidance literature:

With potassium carbonate; In acetone; Heating / reflux;

upstream raw materials:

2,6-difluorophenyl propionate

2,6-difluorophenol

Downstream raw materials:

ethyl 4-(2,6-difluoro-4-propionylphenoxy)butyrate

ethyl 4-(4-(2-bromopropionyl)-2,6-difluorophenoxy)butyrate

3,5-difluoro-4-methoxy-propiophenone

3,5-difluoro-4-methoxybenzoic acid

Refernces