2,6-difluorophenyl propionate

Base Information

Chemical Name:2,6-difluorophenyl propionate
CAS No.:171291-49-9
Molecular Formula:C₉H₈F₂O₂
Molecular Weight:186.158
Hs Code.:

Synonyms:

Suppliers and Price of 2,6-difluorophenyl propionate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2,6-difluorophenyl propionate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2,6-difluorophenyl propionate

There total 1 articles about 2,6-difluorophenyl propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 28177-48-2
2,6-difluorophenol

: 79-03-8
propionyl chloride

: 171291-49-9
2,6-difluorophenyl propionate

Guidance literature:: In acetonitrile; for 18h; Heating;
DOI:10.1016/0957-4166(95)00232-E

Reference yield:

: 171291-49-9
2,6-difluorophenyl propionate

: 178374-78-2
3',5'-difluoro-4'-hydroxypropiophenone

Guidance literature:: With aluminium trichloride; at 90 - 95 ℃; for 2h;
DOI:10.1016/0957-4166(95)00232-E

Reference yield:

: 171291-49-9
2,6-difluorophenyl propionate

: (2S,3S,5R)-ethyl 4-(2,6-difluoro-4-(2-hydroxy-3,5-dimethyl-2-morpholinyl)phenoxy)butyrate hydrobromide

Guidance literature:: Multi-step reaction with 4 steps

1: AlCl₃ / 2 h / 90 - 95 °C

2: 64 percent / EtONa, NaI / ethanol / 18 h / Heating

3: dioxane dibromide / dioxane / 3 h / Ambient temperature

4: 2,6-lutidine / acetonitrile / 120 h / Ambient temperature

With 2,6-dimethylpyridine; aluminium trichloride; 1,4-dioxane dibromide; sodium ethanolate; sodium iodide; In 1,4-dioxane; ethanol; acetonitrile;
DOI:10.1016/0957-4166(95)00232-E