hydroxybenzalaceto-phenone

Base Information

• Chemical Name: hydroxybenzalaceto-phenone
• CAS No.: 1704-15-0
• Molecular Formula: C₁₅H₁₂O₂
• Molecular Weight: 224.259
• Mol file: 1704-15-0.mol

Synonyms:Dibenzoylmethan (enol);2-Propen-1-one,3-hydroxy-1,3-diphenyl-,(Z);dibenzoylmethane;3-hydroxy-1,3-diphenyl-2-propen-1-one;1,3-diphenyl-propane-1,3-dione;2-Propen-1-one, 3-hydroxy-1,3-diphenyl-;

Chemical Property of hydroxybenzalaceto-phenone

Chemical Property:

• Melting Point: 79.8°C
• Refractive Index: 1.6600 (estimate)
• Boiling Point: 325.66°C (rough estimate)
• PKA: 8.37±0.50(Predicted)
• PSA: 37.30000
• Density: 1.1139 (rough estimate)
• LogP: 3.46840

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of hydroxybenzalaceto-phenone

There total 25 articles about hydroxybenzalaceto-phenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

5-benzyloxy-1-phenylpent-2-en-1-one (1056888-83-5) → 3-hydroxy-1,3-diphenyl-2-propen-1-one (1704-15-0,62961-62-0)

Guidance literature:

5-benzyloxy-1-phenylpent-2-en-1-one; With bis(iodozinc)methane; In tetrahydrofuran; at 25 ℃; Inert atmosphere;

With ammonium chloride; In tetrahydrofuran; water; Inert atmosphere;

DOI:10.1021/ja910428y

Reference yield: 96.0%

N'-((3-oxo-1,3-diphenylprop-1-en-1-yl)oxy)benzimidamide (1533419-10-1) → 3-hydroxy-1,3-diphenyl-2-propen-1-one (1704-15-0,62961-62-0)

Guidance literature:

With hydrogenchloride; In dichloromethane; water; at 20 ℃; for 1h;

DOI:10.1016/j.tet.2013.12.043

Reference yield: 95.0%

1,3-diphenyl-2-propynone (7338-94-5) + Benzaldoxime (932-90-1) → 3-hydroxy-1,3-diphenyl-2-propen-1-one (1704-15-0,62961-62-0) + benzonitrile (100-47-0)

Guidance literature:

With triphenylphosphine; In dichloromethane; at 25 ℃; for 3h; Reagent/catalyst; Solvent; Catalytic behavior; Mechanism; Inert atmosphere; Schlenk technique; Sealed tube;

DOI:10.1039/c8ob01861h

upstream raw materials:

methanol

chalcone epoxide

5-benzyloxy-1-phenylpent-2-en-1-one

trans-2,3-epoxy-1,3-diphenyl-1-propanone

Downstream raw materials:

benzoic acid

2-allyl-1,3-diphenyl-1,3-propanedione

2-(2-methylallyl)-1,3-diphenyl-1,3-propanedione

1,3-diphenylpropanedione

Refernces

• 1、 Hemric, Brett N.,Chen, Andy W.,Wang, Qiu. "Copper-Catalyzed Modular Amino Oxygenation of Alkenes: Access to Diverse 1,2-Amino Oxygen-Containing Skeletons". supporting information. p. 1468 - 1488. Retrieved 2019/01/25.
• 2、 Rozatian, Neshat,Beeby, Andrew,Ashworth, Ian W.,Sandford, Graham,Hodgson, David R.W.. "Enolization rates control mono-: Versus di-fluorination of 1,3-dicarbonyl derivatives". . p. 10318 - 10330. Retrieved 2019/11/20.