4-(ACETYLAMINO)-1-BENZYL-4-PHENYLPIPERIDINE

Base Information

• Chemical Name: 4-(ACETYLAMINO)-1-BENZYL-4-PHENYLPIPERIDINE
• CAS No.: 172733-78-7
• Molecular Formula: C20H24N2O
• Molecular Weight: 308.423
• Hs Code.: 2933399090
• Mol file: 172733-78-7.mol

Synonyms:4-Acetamido-1-benzyl-4-phenylpiperidine;

Chemical Property of 4-(ACETYLAMINO)-1-BENZYL-4-PHENYLPIPERIDINE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 491.59oC at 760 mmHg
• Flash Point: 251.105oC
• PSA: 35.83000
• Density: 1.127g/cm3
• LogP: 4.09220

Purity/Quality:

≥99% ^*data from raw suppliers

N-(1-Benzyl-4-phenylpiperidin-4-yl)acetamide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(ACETYLAMINO)-1-BENZYL-4-PHENYLPIPERIDINE

There total 8 articles about 4-(ACETYLAMINO)-1-BENZYL-4-PHENYLPIPERIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

1-benzyl-4-hydroxy-4-phenylpiperidine (63843-83-4) + acetic acid (64-19-7,77671-22-8) → N-(1-benzyl-4-phenylpiperidin-4-yl)acetamide (172733-78-7)

Guidance literature:

With sulfuric acid; In acetonitrile;

DOI:10.1016/0960-894X(96)00419-2

Reference yield: 71.0%

1-benzyl-4-hydroxy-4-phenylpiperidine (63843-83-4) + acetonitrile (75-05-8,26809-02-9) → N-(1-benzyl-4-phenylpiperidin-4-yl)acetamide (172733-78-7)

Guidance literature:

With sulfuric acid; at 0 - 20 ℃;

DOI:10.1016/j.bmc.2011.07.002

Reference yield: 33.0%

bromobenzene (108-86-1,52753-63-6) + 1-benzyl-4-(trifluoromethylsulfonyloxy)-1,2,5,6-tetrahydropyridine (126781-38-2) + acetonitrile (75-05-8,26809-02-9) → N-(1-benzyl-4-phenylpiperidin-4-yl)acetamide (172733-78-7)

Guidance literature:

bromobenzene; With tert.-butyl lithium; In tetrahydrofuran; at -78 ℃; for 0.5h; Inert atmosphere;

With bromo(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)dimethylgermane; In tetrahydrofuran; at -78 ℃; for 16h; Inert atmosphere;

1-benzyl-4-(trifluoromethylsulfonyloxy)-1,2,5,6-tetrahydropyridine; acetonitrile; Further stages;

DOI:10.1039/b816217b

upstream raw materials:

1-benzyl-4-hydroxy-4-phenylpiperidine

acetic acid

1-phenylmethyl-4-piperidone

phenyllithium

Downstream raw materials:

N-((S)-2-amino-3-((S)-1-((S)-1-((2S,3R)-4-(1-benzyl-4-phenylpiperidin-4-ylamino)-3-hydroxy-4-oxo-1-phenylbutan-2-ylamino)-3-cyclohexyl-1-oxopropan-2-ylamino)-3-methyl-1-oxobutan-2-ylamino)-3-oxopropyl)-2,5-dihydroxybenzamide

N-((S)-2-amino-3-((S)-1-((S)-1-((2S,3R)-4-(1-benzyl-4-phenylpiperidin-4-ylamino)-3-hydroxy-4-oxo-1-phenylbutan-2-ylamino)-4-methyl-1-oxopentan-2-ylamino)-3-methyl-1-oxobutan-2-ylamino)-3-oxopropyl)-2,5-dihydroxybenzamide

Refernces

• 1、 Nitta, Aiko,Fujii, Hideaki,Sakami, Satoshi,Nishimura, Yutaka,Ohyama, Tomofumi,Satoh, Mikiya,Nakaki, Junko,Satoh, Shiho,Inada, Chifumi,Kozono, Hideki,Kumagai, Hiroki,Shimamura, Masahiro,Fukazawa, Tominaga,Kawai, Hideki. "(3R)-3-Amino-4-(2,4,5-trifluorophenyl)-N-{4-[6-(2-methoxyethoxy)benzothiazol-2-yl]tetrahydropyran-4-yl}butanamide as a potent dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes". scheme or table. p. 5435 - 5438. Retrieved 2009/05/30.
• 2、 -. "SUBSTITUTED HETEROCYCLIC COMPOUNDS METHOD OF PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS IN WHICH THEY ARE PRESENT". . . Retrieved 2008/06/13.